Regression patterns of uveal melanomas after proton beam irradiation

Journal Article · Thu Jul 01 00:00:00 EDT 1982 · Ophthalmology (Rochester, Minn.); (United States)

DOI:https://doi.org/10.1016/S0161-6420(82)34731-4· OSTI ID:6564532

Wilkes, S R; Gragoudas, E S

Forty-four uveal melanomas were evaluated for patterns of tumor regression after proton beam irradiation. All tumors were followed for a minimum of ten months after treatment. Seven lesions completely disappeared, 33 have decreased in size, and 4 remained unchanged. Associated signs of tumor regression were: resolution of the secondary serous retinal detachments, central apical yellow discoloration of the tumor, destruction of the tumor's vasculature, and elimination of fluorescein leakage. This study demonstrated that regression after proton beam irradiation is a relatively slow process, and the effects of radiation could be observed in some cases more than a year after treatment.

• Research Organization: Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School
• OSTI ID: 6564532
• Journal Information: Ophthalmology (Rochester, Minn.); (United States), Vol. 89:7
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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RADIOTHERAPY
UVEA
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PROTON BEAMS
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