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Title: Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice

Abstract

The transplantation of bone marrow cells from BALB/c (but not C57BL/6 and C3H/HeN) mice was observed to lead to the development of thymic lymphomas (leukemias) in AKR/J mice. Two leukemic cell lines, CAK1.3 and CAK4.4, were established from the primary culture of two thymic lymphoma, and surface phenotypes of these cell lines found to be H-2d and Thy-1.2+, indicating that these lymphoma cells are derived from BALB/c donor bone marrow cells. Further analyses of surface markers revealed that CAK1.3 is L3T4+ Lyt2+ IL2R-, whereas CAK4.4 is L3T4- Lyt2- IL2R+. Both CAK1.3 and CAK4.4 were transplantable into BALB/c but not AKR/J mice, further indicating that these cells are of BALB/c bone marrow donor origin. The cells were found to produce XC+-ecotropic viruses, but xenotropic and mink cell focus-forming viruses were undetectable. Inasmuch as thymic lymphomas are derived from bone marrow cells of leukemia-resistant BALB/c strain of mice under the allogeneic environment of leukemia-prone AKR/J mice, this animal model may serve as a useful tool not only for the analysis of leukemic relapse after bone marrow transplantation but also for elucidation of the mechanism of leukemogenesis.

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Kansai Medical Univ., Osaka (Japan)
OSTI Identifier:
6557248
Resource Type:
Journal Article
Journal Name:
J. Immunol.; (United States)
Additional Journal Information:
Journal Volume: 141:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; TRANSPLANTS; THYMUS; LYMPHOMAS; BIOLOGICAL MODELS; LEUKEMIA; MICE; PHENOTYPE; RADIATION CHIMERAS; VIRUSES; ANIMAL TISSUES; ANIMALS; BODY; CHIMERAS; DISEASES; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; LYMPHATIC SYSTEM; MAMMALS; MICROORGANISMS; MOSAICISM; NEOPLASMS; ORGANS; PARASITES; RODENTS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Yasumizu, R., Hiai, H., Sugiura, K., Oyaizu, N., Fan, H.X., Ohnishi, Y., Iwai, H., Inaba, M., Kakinuma, M., and Onoe, K.. Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice. United States: N. p., 1988. Web.
Yasumizu, R., Hiai, H., Sugiura, K., Oyaizu, N., Fan, H.X., Ohnishi, Y., Iwai, H., Inaba, M., Kakinuma, M., & Onoe, K.. Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice. United States.
Yasumizu, R., Hiai, H., Sugiura, K., Oyaizu, N., Fan, H.X., Ohnishi, Y., Iwai, H., Inaba, M., Kakinuma, M., and Onoe, K.. Thu . "Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice". United States.
@article{osti_6557248,
title = {Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice},
author = {Yasumizu, R. and Hiai, H. and Sugiura, K. and Oyaizu, N. and Fan, H.X. and Ohnishi, Y. and Iwai, H. and Inaba, M. and Kakinuma, M. and Onoe, K.},
abstractNote = {The transplantation of bone marrow cells from BALB/c (but not C57BL/6 and C3H/HeN) mice was observed to lead to the development of thymic lymphomas (leukemias) in AKR/J mice. Two leukemic cell lines, CAK1.3 and CAK4.4, were established from the primary culture of two thymic lymphoma, and surface phenotypes of these cell lines found to be H-2d and Thy-1.2+, indicating that these lymphoma cells are derived from BALB/c donor bone marrow cells. Further analyses of surface markers revealed that CAK1.3 is L3T4+ Lyt2+ IL2R-, whereas CAK4.4 is L3T4- Lyt2- IL2R+. Both CAK1.3 and CAK4.4 were transplantable into BALB/c but not AKR/J mice, further indicating that these cells are of BALB/c bone marrow donor origin. The cells were found to produce XC+-ecotropic viruses, but xenotropic and mink cell focus-forming viruses were undetectable. Inasmuch as thymic lymphomas are derived from bone marrow cells of leukemia-resistant BALB/c strain of mice under the allogeneic environment of leukemia-prone AKR/J mice, this animal model may serve as a useful tool not only for the analysis of leukemic relapse after bone marrow transplantation but also for elucidation of the mechanism of leukemogenesis.},
doi = {},
journal = {J. Immunol.; (United States)},
number = ,
volume = 141:6,
place = {United States},
year = {1988},
month = {9}
}