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Title: Long-term persistence of human anti-murine antibody responses following radioimmunodetection and radioimmunotherapy of cutaneous T-cell lymphoma patients using /sup 131/I-T101

Abstract

Five cutaneous T-cell lymphoma (CTCL) patients have been imaged and treated with radiolabeled murine monoclonal antibody /sup 131/I-T101 in our laboratory. All patients developed human anti-murine antibody responses (HAMA) 14 days after the primary antibody infusion. HAMA responses could still be detected more than 22 months after T101 treatment. A substantial proportion of HAMA was crossreactive with any IgG2a antibody tested, although there did exist a specific anti-idiotypic component to HAMA. HAMA were of both IgM and IgG isotype. We also analyzed the effects of plasmapheresis on the specific HAMA isotypes in three patients who were retreated at the time of disease progression.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Northwestern Univ., Chicago, IL (USA)
OSTI Identifier:
6555132
Resource Type:
Journal Article
Journal Name:
Exp. Hematol.; (United States)
Additional Journal Information:
Journal Volume: 16:10
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IMMUNE SYSTEM DISEASES; RADIOINDUCTION; RADIOIMMUNOASSAY; SIDE EFFECTS; RADIOIMMUNOTHERAPY; IODINE 131; LYMPHOMAS; MONOCLONAL ANTIBODIES; PATIENTS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; IMMUNOASSAY; IMMUNOLOGY; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; RADIOASSAY; RADIOIMMUNOLOGY; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; THERAPY; TRACER TECHNIQUES; 560151* - Radiation Effects on Animals- Man

Citation Formats

Goldman-Leikin, R E, Kaplan, E H, Zimmer, A M, Kazikiewicz, J, Manzel, L J, and Rosen, S T. Long-term persistence of human anti-murine antibody responses following radioimmunodetection and radioimmunotherapy of cutaneous T-cell lymphoma patients using /sup 131/I-T101. United States: N. p., 1988. Web.
Goldman-Leikin, R E, Kaplan, E H, Zimmer, A M, Kazikiewicz, J, Manzel, L J, & Rosen, S T. Long-term persistence of human anti-murine antibody responses following radioimmunodetection and radioimmunotherapy of cutaneous T-cell lymphoma patients using /sup 131/I-T101. United States.
Goldman-Leikin, R E, Kaplan, E H, Zimmer, A M, Kazikiewicz, J, Manzel, L J, and Rosen, S T. 1988. "Long-term persistence of human anti-murine antibody responses following radioimmunodetection and radioimmunotherapy of cutaneous T-cell lymphoma patients using /sup 131/I-T101". United States.
@article{osti_6555132,
title = {Long-term persistence of human anti-murine antibody responses following radioimmunodetection and radioimmunotherapy of cutaneous T-cell lymphoma patients using /sup 131/I-T101},
author = {Goldman-Leikin, R E and Kaplan, E H and Zimmer, A M and Kazikiewicz, J and Manzel, L J and Rosen, S T},
abstractNote = {Five cutaneous T-cell lymphoma (CTCL) patients have been imaged and treated with radiolabeled murine monoclonal antibody /sup 131/I-T101 in our laboratory. All patients developed human anti-murine antibody responses (HAMA) 14 days after the primary antibody infusion. HAMA responses could still be detected more than 22 months after T101 treatment. A substantial proportion of HAMA was crossreactive with any IgG2a antibody tested, although there did exist a specific anti-idiotypic component to HAMA. HAMA were of both IgM and IgG isotype. We also analyzed the effects of plasmapheresis on the specific HAMA isotypes in three patients who were retreated at the time of disease progression.},
doi = {},
url = {https://www.osti.gov/biblio/6555132}, journal = {Exp. Hematol.; (United States)},
number = ,
volume = 16:10,
place = {United States},
year = {Tue Nov 01 00:00:00 EST 1988},
month = {Tue Nov 01 00:00:00 EST 1988}
}