Imaging the inflammatory response to acute myocardial infarction in man using indium-111-labeled autologous platelets
The feasibility of imaging the inflammatory response to acute transmural myocardial infarction in man using indium-111 (/sup 111/In)-labeled autologous leukocytes was assessed in 36 patients. Indium-111 leukocytes were injected i.v. 18 to 112 hs after the onset of chest pain. Cardiac imaging was performed 24 hs later with a mobile gamma camera. Twenty-one patients had positive images and 15 had negative images. The percent of positive images increased as the interval between infarction and /sup 111/In-leukocyte injection shortened; all patients injected within 24 hs of infarction had positive images. Patients with positive images were injected with /sup 111/In leukocytes earlier after infarction and were younger than those with negative images. Several other parameters that could possibly have affected the imaging results were examined and were not significantly different in patients with positive and negative images. These included peak serum creatine kinase, location of infarction, incidence of pericarditis, use of antiinflammatory drugs or membrane-active antiarrhythmic drugs, peripheral leukocyte count, and cell labeling efficiency. The function of the labeled cells was similar in patients with positive and negative images. Six patients with acute infarction serving as controls and given free /sup 111/In-oxine and six patients with stable coronary artery disease given /sup 111/In-leukocytes all had negative cardiac images.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- DOE Contract Number:
- EY-76-S-02-4078
- OSTI ID:
- 6551801
- Journal Information:
- Circulation; (United States), Vol. 63:4
- Country of Publication:
- United States
- Language:
- English
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INDIUM 111
RADIOPHARMACEUTICALS
SCINTISCANNING
INFLAMMATION
DIAGNOSIS
LEUKOCYTES
MYOCARDIAL INFARCTION
MYOCARDIUM
COMPARATIVE EVALUATIONS
MAN
OXINE
PATIENTS
STATISTICS
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MATHEMATICS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
PYRIDINES
QUINOLINES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics