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Title: Initial Experimental Verification of the Neutron Beam Modeling for the LBNL BNCT Facility

Abstract

In preparation for future clinical BNCT trials, neutron production via the 7Li(p,n) reaction as well as subsequent moderation to produce epithermal neutrons have been studied. Proper design of a moderator and filter assembly is crucial in producing an optimal epithermal neutron spectrum for brain tumor treatments. Based on in-phantom figures-of-merit,desirable assemblies have been identified. Experiments were performed at the Lawrence Berkeley National Laboratory's 88-inch cyclotron to characterize epithermal neutron beams created using several microampere of 2.5 MeV protons on a lithium target. The neutron moderating assembly consisted of Al/AlF3 and Teflon, with a lead reflector to produce an epithermal spectrum strongly peaked at 10-20 keV. The thermal neutron fluence was measured as a function of depth in a cubic lucite head phantom by neutron activation in gold foils. Portions of the neutron spectrum were measured by in-air activation of six cadmium-covered materials (Au, Mn, In, Cu, Co, W) with high epithermal neutron absorption resonances. The results are reasonably reproduced in Monte Carlo computational models, confirming their validity.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (US)
OSTI Identifier:
6540
Report Number(s):
LBNL-42956
TRN: US0406705
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Conference
Resource Relation:
Conference: The 15th International Conference on the Application of Accelerators in Research and Industry (CAARI), Conference location not supplied, Conference dates not supplied; Other Information: PBD: 19 Jan 1999
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; ABSORPTION; ACCELERATORS; BRAIN; CYCLOTRONS; EPITHERMAL NEUTRONS; GOLD; LITHIUM; LUCITE; MODERATORS; NEOPLASMS; NEUTRON BEAMS; NEUTRONS; PHANTOMS; PROTONS; SIMULATION; TEFLON; THERMAL NEUTRONS; VERIFICATION

Citation Formats

Bleuel, D.L., Chu, W.T., Donahue, R.J., Ludewigt, B.A., McDonald, R.J., Smith, A.R., Stone, N.A., and Vuji, J. Initial Experimental Verification of the Neutron Beam Modeling for the LBNL BNCT Facility. United States: N. p., 1999. Web.
Bleuel, D.L., Chu, W.T., Donahue, R.J., Ludewigt, B.A., McDonald, R.J., Smith, A.R., Stone, N.A., & Vuji, J. Initial Experimental Verification of the Neutron Beam Modeling for the LBNL BNCT Facility. United States.
Bleuel, D.L., Chu, W.T., Donahue, R.J., Ludewigt, B.A., McDonald, R.J., Smith, A.R., Stone, N.A., and Vuji, J. Tue . "Initial Experimental Verification of the Neutron Beam Modeling for the LBNL BNCT Facility". United States. doi:. https://www.osti.gov/servlets/purl/6540.
@article{osti_6540,
title = {Initial Experimental Verification of the Neutron Beam Modeling for the LBNL BNCT Facility},
author = {Bleuel, D.L. and Chu, W.T. and Donahue, R.J. and Ludewigt, B.A. and McDonald, R.J. and Smith, A.R. and Stone, N.A. and Vuji, J.},
abstractNote = {In preparation for future clinical BNCT trials, neutron production via the 7Li(p,n) reaction as well as subsequent moderation to produce epithermal neutrons have been studied. Proper design of a moderator and filter assembly is crucial in producing an optimal epithermal neutron spectrum for brain tumor treatments. Based on in-phantom figures-of-merit,desirable assemblies have been identified. Experiments were performed at the Lawrence Berkeley National Laboratory's 88-inch cyclotron to characterize epithermal neutron beams created using several microampere of 2.5 MeV protons on a lithium target. The neutron moderating assembly consisted of Al/AlF3 and Teflon, with a lead reflector to produce an epithermal spectrum strongly peaked at 10-20 keV. The thermal neutron fluence was measured as a function of depth in a cubic lucite head phantom by neutron activation in gold foils. Portions of the neutron spectrum were measured by in-air activation of six cadmium-covered materials (Au, Mn, In, Cu, Co, W) with high epithermal neutron absorption resonances. The results are reasonably reproduced in Monte Carlo computational models, confirming their validity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 19 00:00:00 EST 1999},
month = {Tue Jan 19 00:00:00 EST 1999}
}

Conference:
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