Recent advances in regenerable fiber-optic-based immunosensors

Title: Recent advances in regenerable fiber-optic-based immunosensors

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Abstract

For the past few years our group has been interested in increasing the selectivity in analytical luminescence spectroscopy for remote analysis. To this end, we have been investigating the use of multidimensional dynamic fluorescence spectroscopy in concert with small fiber-optic-based probes. By using the inherent multidimensionality of fluorescence with fiber optic sensing we have managed to simultaneously increase selectivity and perform remote analysis. In this presentation we will discuss our progress in the use of fluorescently-labeled F{sub ab{prime}} antibody fragments covalently attached to the distal end of a simple fiber-optic probe. This new generation of fiber-optic probes are simple to construct, robust, and easily reused after pH reconditioning.

Authors:

Bright, F V; Litwiler, K S ^[1]

State Univ. of New York, Buffalo (USA)

Publication Date:: 1990-01-01

OSTI Identifier:: 6534263

Report Number(s):: CONF-900402-
Journal ID: ISSN 0093-3066; CODEN: ACEPC

Resource Type:: Conference

Journal Name:: American Chemical Society, Division of Environmental Chemistry, Preprints; (USA)

Additional Journal Information:: Journal Volume: 30:1; Conference: 199. national meeting of the American Chemical Society, Boston, MA (USA), 22-27 Apr 1990; Journal ID: ISSN 0093-3066

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; FIBER OPTICS; PROBES; CONSTRUCTION; ANTIBODIES; DATA ANALYSIS; FLUORESCENCE; IMMUNOASSAY; MEASURING INSTRUMENTS; MEASURING METHODS; PROCEEDINGS; REMOTE SENSING; BIOASSAY; DOCUMENT TYPES; LUMINESCENCE; 550200* - Biochemistry

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                    Bright, F V, and Litwiler, K S. Recent advances in regenerable fiber-optic-based immunosensors.  United States: N. p., 1990. 
        Web.

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                    Bright, F V, & Litwiler, K S. Recent advances in regenerable fiber-optic-based immunosensors.  United States.

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                    Bright, F V, and Litwiler, K S. Mon .  
        "Recent advances in regenerable fiber-optic-based immunosensors".  United States.

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@article{osti_6534263,

  title        = {Recent advances in regenerable fiber-optic-based immunosensors},

  author       = {Bright, F V and Litwiler, K S},

  abstractNote = {For the past few years our group has been interested in increasing the selectivity in analytical luminescence spectroscopy for remote analysis. To this end, we have been investigating the use of multidimensional dynamic fluorescence spectroscopy in concert with small fiber-optic-based probes. By using the inherent multidimensionality of fluorescence with fiber optic sensing we have managed to simultaneously increase selectivity and perform remote analysis. In this presentation we will discuss our progress in the use of fluorescently-labeled F{sub ab{prime}} antibody fragments covalently attached to the distal end of a simple fiber-optic probe. This new generation of fiber-optic probes are simple to construct, robust, and easily reused after pH reconditioning.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6534263},
  journal      = {American Chemical Society, Division of Environmental Chemistry, Preprints; (USA)},

  issn         = {0093-3066},

  number       = ,

  volume       = 30:1,

  place        = {United States},

  year         = {1990},

  month        = {1}

}

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