System for cerebral blood flow measurement using an H/sub 2//sup 15/O autoradiographic method and positron emission tomography

Journal Article · Wed Apr 01 00:00:00 EST 1987 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1987.37· OSTI ID:6522481

Kanno, I; Iida, H; Miura, S; Murakami, M; Takahashi, K; Sasaki, H; Inugami, A; Shishido, F; Uemura, K

A system for CBF measurement using an H/sub 2//sup 15/O autoradiographic method and positron emission tomography (PET) has been designed and installed as a clinical tool. Following an intravenous injection of H/sub 2//sup 15/O, a radioactivity accumulation in the brain tissue for 60 s and a continuous record of radioactivity in arterial blood were measured by a high counting speed PET device and a beta-ray detector, respectively, and CBF was calculated by a table-lookup procedure. First, this method was compared with the C/sup 15/O/sub 2/ inhalation steady-state method on 17 cerebrovascular disease patients and four normal subjects. The two values for CBF agreed with each other when H/sub 2//sup 15/O autoradiographic method was applied by correction for the dispersion in the measured arterial radioactivity-time curve. However, without the correction, the CBF by the H/sub 2//sup 15/O autoradiographic method revealed substantial overestimation by 30.6 +/- 17.5%. A reduced gray/white ratio of CBF was also observed in the H/sub 2//sup 15/O autoradiographic method. Second, simulation was performed in order to determine optimal accumulation time by PET scan; the result was that errors due to dispersion and time mismatch became critical as the accumulation time was shortened to less than 60 s.

• Research Organization: Research Institute of Brain and Blood Vessels, Akita, Japan
• OSTI ID: 6522481
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
MEASURING METHODS
BRAIN
POSITRON COMPUTED TOMOGRAPHY
VASCULAR DISEASES
DIAGNOSIS
AUTORADIOGRAPHY
DYNAMIC FUNCTION STUDIES
OXYGEN 15
PATIENTS
WATER
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
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