Pulmonary effects and clearance of intratracheally instilled Ni/sub 3/S/sub 2/ and TiO/sub 2/ in mice

Journal Article · Sun Feb 01 00:00:00 EST 1987 · Environ. Res.; (United States)

OSTI ID:6515742

Finch, G L; Fisher, G L; Hayes, T L

The effects and clearance of intratracheally instilled nickel subsulfide (Ni/sub 3/S/sub 2/) and titanium dioxide (TiO/sub 2/) were compared. Instilled Ni/sub 3/S/sub 2/ was acutely toxic to mice. Blood was recovered from the lungs during lavage, pulmonary polymorphonuclear leukocyte cell levels were increased, body weights decreased, and mice appeared clinically sick. These effects were in contrast to TiO/sub 2/-instilled animals, which appeared similar to phosphate-buffered saline-instilled controls. The clearance of instilled particles from the lungs was examined for both Ni/sub 3/S/sub 2/- and TiO/sub 2/-exposed mice. Particles were rapidly cleared to the gastrointestinal (GI) tract within 15 min; this clearance was nonspecific for Ni or Ti and appeared to be due to the coughing reflex. Significantly less Ni was present compared with TiO/sub 2/ in mouse lungs at 3 and 7 days postexposure, with halflifes for the later clearance phase of 119 and 462 hr, respectively. Much of the early Ni lung burden was cleared to the GI tract, and Ni levels in the kidney and blood peaked at 1 hr. Longer-term Ni clearance rate constants were similar for lung, kidney, and blood and were consistent with the hypothesis that /sup 63/Ni was first solubilized in the lung then transported through the blood.

• Research Organization: Lawrence Berkeley Lab., CA
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 6515742
• Journal Information: Environ. Res.; (United States), Vol. 42:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
NICKEL 63
TRANSLOCATION
NICKEL SULFIDES
LUNG CLEARANCE
TOXICITY
TITANIUM OXIDES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BLOOD
GASTROINTESTINAL TRACT
INHALATION
INTRATRACHEAL ADMINISTRATION
KIDNEYS
LUNGS
MICE
PATHOLOGICAL CHANGES
RESPONSE MODIFYING FACTORS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHALCOGENIDES
CLEARANCE
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
EXCRETION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MATERIALS
NICKEL COMPOUNDS
NICKEL ISOTOPES
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SULFIDES
SULFUR COMPOUNDS
TITANIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology
550500 - Metabolism