Genetic and animal toxicity testing of SRC-I products, intermediates, and waste materials: Final report: Appendix F, First-stage middle distillate dermal carcinogenesis studies
We have completed an extensive program to investigate the toxicity---including mutagenic,, carcinogenic, and teratogenic potential---of SRC-I (Solvent Refined Coal-I) products, along with selected intermediates and waste materials, as represented by the SRC-I Design Baseline. The original primary objective of the toxicology program was to produce data that could be used for four main purposes: to support design of programs to ensure workers' health and safety; to help estimate environmental impacts of SRC-I technology; to support the Toxic Substances Control Act (TSCA) premanufacturing notification process for SRC-I technology; and to promote public understanding and acceptance of the potential health effects of the emerging synfuels industry. The toxicology program consists of five main elements: (1) Genetic Toxicity Evaluations; (2) Acute Animal Toxicity Evaluations; (3) Subchronic Animal Toxicity Evaluations; (4) Chronic (life-span) Animal Carcinogenicity Evaluation; (5) Quality Control/Quality Assurance (QC/QA) Monitoring and Evaluation.
- Research Organization:
- Air Products and Chemicals, Inc., Allentown, PA (USA)
- DOE Contract Number:
- AC05-84OR21446
- OSTI ID:
- 6504563
- Report Number(s):
- DOE/OR/21446-T1-App.F; ON: DE89006276
- Resource Relation:
- Other Information: Paper copy only, copy does not permit microfiche production
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BY-PRODUCTS
BIOLOGICAL EFFECTS
SOLVENT-REFINED COAL
TOXICITY
CARCINOGENESIS
GENETIC EFFECTS
MICE
MODIFICATIONS
MONITORING
MUTAGENESIS
PROGRESS REPORT
QUALITY CONTROL
RATS
SKIN
TERATOGENESIS
TIME DEPENDENCE
ANIMALS
BODY
CONTROL
DOCUMENT TYPES
FUELS
MAMMALS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
016000* - Coal
Lignite
& Peat- Health & Safety
010900 - Coal
Lignite
& Peat- Environmental Aspects