Genetic and animal toxicity testing of SRC-I products, intermediates, and waste materials: Final report: Appendix G, Second-stage middle distillate dermal carcinogenesis studies
We have completed an extensive program to investigate the toxicity---including mutagenic, carcinogenic, and teratogenic potential---of SRC-I (Solvent Refined Coal-I) products, along with selected intermediates and waste materials, as represented by the SRC-I Design Baseline. The original primary objective of the toxicology program was to produce data that could be used for four main purposes: to support design of programs to ensure workers' health and safety; to help estimate environmental impacts of SRC-I technology; to support the Toxic Substances Control Act (TSCA) premanufacturing notification process for SRC-I technology; and to promote public understanding and acceptance of the potential health effects of the emerging synfuels industry. The toxicology program consists of five main elements: (1) Genetic Toxicity Evaluations; (2) Acute Animal Toxicity Evaluations; (3) Subchronic Animal Toxicity Evaluations; (4) Chronic (life-span) Animal Carcinogenicity Evaluation; (5) Quality Control/Quality Assurance (QC/QA) Monitoring and Evaluation.
- Research Organization:
- Air Products and Chemicals, Inc., Allentown, PA (USA)
- DOE Contract Number:
- AC05-84OR21446
- OSTI ID:
- 6504540
- Report Number(s):
- DOE/OR/21446-T1-App.G; ON: DE89006277
- Resource Relation:
- Other Information: Paper copy only, copy does not permit microfiche production
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BY-PRODUCTS
BIOLOGICAL EFFECTS
SOLVENT-REFINED COAL
TOXICITY
CARCINOGENESIS
GENETIC EFFECTS
MICE
MODIFICATIONS
MONITORING
MUTAGENESIS
PROGRESS REPORT
RATS
SKIN
TERATOGENESIS
ANIMALS
BODY
DOCUMENT TYPES
FUELS
MAMMALS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
016000* - Coal
Lignite
& Peat- Health & Safety
010900 - Coal
Lignite
& Peat- Environmental Aspects