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Title: Clinical studies on the use of radiation therapy as primary treatment of early breast cancer

Abstract

The treatment of operable breast cancer by primary radiation therapy instead of mastectomy is undergoing evaluation in the United States and Europe. Retrospective studies of patients treated by primary radiation therapy show that local control and survival rates are comparable to those obtained by mastectomy. Detailed analysis of local failure following primary radiation therapy indicates the importance of excisional biopsy of the primary tumor, moderate doses of radiation to the breast and draining lymph node areas, and the use of a boost to the primary tumor area in maximizing local control. Further, the judicious use of local excision combined with meticulous radiotherapy technique yields highly satisfactory results for the majority of treated patients. Preliminary results from prospective trials also indicate that primary radiation therapy provides both local control and survival rates equivalent to mastectomy. Primary radiation therapy is becoming an increasingly important alternative to mastectomy where surgical and radiotherapeutic expertise are available to optimize both local tumor control and the final cosmetic outcome.

Authors:
; ;
Publication Date:
Research Org.:
Harvard Medical School, Boston, MA
OSTI Identifier:
6500868
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 53:3 Suppl
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; RADIOTHERAPY; MAMMARY GLANDS; EVALUATION; PATIENTS; SURGERY; BODY; DISEASES; GLANDS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Harris, J R, Beadle, G F, and Hellman, S. Clinical studies on the use of radiation therapy as primary treatment of early breast cancer. United States: N. p., 1984. Web. doi:10.1002/1097-0142(19840201)53:3+<705::AID-CNCR2820531319>3.0.CO;2-L.
Harris, J R, Beadle, G F, & Hellman, S. Clinical studies on the use of radiation therapy as primary treatment of early breast cancer. United States. https://doi.org/10.1002/1097-0142(19840201)53:3+<705::AID-CNCR2820531319>3.0.CO;2-L
Harris, J R, Beadle, G F, and Hellman, S. 1984. "Clinical studies on the use of radiation therapy as primary treatment of early breast cancer". United States. https://doi.org/10.1002/1097-0142(19840201)53:3+<705::AID-CNCR2820531319>3.0.CO;2-L.
@article{osti_6500868,
title = {Clinical studies on the use of radiation therapy as primary treatment of early breast cancer},
author = {Harris, J R and Beadle, G F and Hellman, S},
abstractNote = {The treatment of operable breast cancer by primary radiation therapy instead of mastectomy is undergoing evaluation in the United States and Europe. Retrospective studies of patients treated by primary radiation therapy show that local control and survival rates are comparable to those obtained by mastectomy. Detailed analysis of local failure following primary radiation therapy indicates the importance of excisional biopsy of the primary tumor, moderate doses of radiation to the breast and draining lymph node areas, and the use of a boost to the primary tumor area in maximizing local control. Further, the judicious use of local excision combined with meticulous radiotherapy technique yields highly satisfactory results for the majority of treated patients. Preliminary results from prospective trials also indicate that primary radiation therapy provides both local control and survival rates equivalent to mastectomy. Primary radiation therapy is becoming an increasingly important alternative to mastectomy where surgical and radiotherapeutic expertise are available to optimize both local tumor control and the final cosmetic outcome.},
doi = {10.1002/1097-0142(19840201)53:3+<705::AID-CNCR2820531319>3.0.CO;2-L},
url = {https://www.osti.gov/biblio/6500868}, journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 53:3 Suppl,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 1984},
month = {Wed Feb 01 00:00:00 EST 1984}
}