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Title: Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: spontaneous recovery from the neutrophil abnormalities during early childhood

Abstract

Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8-month-old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N-formyl-methionyl-leucyl-phenylalanine (/sup 3/H-FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (less than 3 SD) as compared with those of control cells of 52,000 +/- 6000 (mean +/- SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Shinshu Univ. School of Medicine, Matsumoto, Japan
OSTI Identifier:
6499313
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. J. Hematol.; (United States); Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; HEMIC DISEASES; PATHOGENESIS; NEUTROPHILS; RECEPTORS; BIOLOGICAL RECOVERY; CHILDREN; PATIENTS; PHENYLALANINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AGE GROUPS; AMINO ACIDS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; DISEASES; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; LEUKOCYTES; MATERIALS; MEMBRANE PROTEINS; ORGANIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; RECOVERY; 550901* - Pathology- Tracer Techniques

Citation Formats

Yasui, K., Yamazaki, M., Miyagawa, Y., Komiyama, A., and Akabane, T. Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: spontaneous recovery from the neutrophil abnormalities during early childhood. United States: N. p., 1987. Web. doi:10.1002/ajh.2830250107.
Yasui, K., Yamazaki, M., Miyagawa, Y., Komiyama, A., & Akabane, T. Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: spontaneous recovery from the neutrophil abnormalities during early childhood. United States. doi:10.1002/ajh.2830250107.
Yasui, K., Yamazaki, M., Miyagawa, Y., Komiyama, A., and Akabane, T. Fri . "Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: spontaneous recovery from the neutrophil abnormalities during early childhood". United States. doi:10.1002/ajh.2830250107.
@article{osti_6499313,
title = {Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: spontaneous recovery from the neutrophil abnormalities during early childhood},
author = {Yasui, K. and Yamazaki, M. and Miyagawa, Y. and Komiyama, A. and Akabane, T.},
abstractNote = {Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8-month-old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N-formyl-methionyl-leucyl-phenylalanine (/sup 3/H-FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (less than 3 SD) as compared with those of control cells of 52,000 +/- 6000 (mean +/- SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder.},
doi = {10.1002/ajh.2830250107},
journal = {Am. J. Hematol.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {Fri May 01 00:00:00 EDT 1987},
month = {Fri May 01 00:00:00 EDT 1987}
}