Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: spontaneous recovery from the neutrophil abnormalities during early childhood

Journal Article · Fri May 01 00:00:00 EDT 1987 · Am. J. Hematol.; (United States)

DOI:https://doi.org/10.1002/ajh.2830250107· OSTI ID:6499313

Yasui, K; Yamazaki, M; Miyagawa, Y; Komiyama, A; Akabane, T

Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8-month-old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N-formyl-methionyl-leucyl-phenylalanine (/sup 3/H-FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (less than 3 SD) as compared with those of control cells of 52,000 +/- 6000 (mean +/- SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder.

• Research Organization: Shinshu Univ. School of Medicine, Matsumoto, Japan
• OSTI ID: 6499313
• Journal Information: Am. J. Hematol.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HEMIC DISEASES
PATHOGENESIS
NEUTROPHILS
RECEPTORS
BIOLOGICAL RECOVERY
CHILDREN
PATIENTS
PHENYLALANINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AGE GROUPS
AMINO ACIDS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
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DISEASES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MATERIALS
MEMBRANE PROTEINS
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ORGANIC COMPOUNDS
PROTEINS
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550901* - Pathology- Tracer Techniques