Effect of anti-B16 melanoma monoclonal antibody on established murine B16 melanoma liver metastases

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Cancer Res.; (United States)

OSTI ID:6477917

Eisenthal, A; Lafreniere, R; Lefor, A T; Rosenberg, S A

The administration of anti-B16 monoclonal antibody of the IgG2b isotype to mice bearing established B16 melanoma liver metastases caused a significant and consistent reduction of up to 90% in the number of these metastases. No reduction in the number of metastases was noted when antigenically unrelated tumor or nonspecific immunoglobulin were employed. The antibody-mediated antitumor effect was completely abrogated by total body irradiation of the host. Treatment of the tumor-bearing host with antiserum directed against asialo GM1 prior to anti B16 antibody administration, abrogated the therapeutic effect indicating the involvement of a radiosensitive, ASGM1-positive cell in the tumor regression. The antitumor effect of the antibody treatment could be augmented by the concomitant administration of recombinant interleukin-2. The effect seen may have possible application in the treatment of liver metastases in humans by combined immunotherapy using recombinant interleukin-2 and specific antitumor monoclonal antibodies.

• Research Organization: National Cancer Institute, Bethesda, MD
• OSTI ID: 6477917
• Journal Information: Cancer Res.; (United States), Vol. 11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNE REACTIONS
BIOLOGICAL RADIATION EFFECTS
LYMPHOKINES
THERAPEUTIC USES
MELANOMAS
IMMUNOTHERAPY
MONOCLONAL ANTIBODIES
IMMUNITY
LIVER
MICE
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
GLANDS
GROWTH FACTORS
MAMMALS
MITOGENS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RODENTS
THERAPY
USES
VERTEBRATES
550600* - Medicine
560152 - Radiation Effects on Animals- Animals