Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Mol. Cell. Biol.; (United States)

DOI:https://doi.org/10.1128/MCB.8.7.2896· OSTI ID:6465755

Sternberg, E A; Spizz, G; Perry, W M; Vizard, D; Weil, T; Olson, E N

Terminal differentiation of skeletal myobalsts is accompanied by induction of a series of tissue-specific gene products, which includes the muscle isoenzymte of creatine kinase (MCK). To begin to define the sequences and signals involved in MCK regulation in developing muscle cells, the mouse MCK gene has been isolated. Sequence analysis of 4,147 bases of DNA surrounding the transcription initiation site revealed several interesting structural features, some of which are common to other muscle-specific genes and to cellular and viral enhancers.

• Research Organization: Dept. of Biochemistry and Molecular Biology, the Univ. of Texas, M.D. Anderson Hospital and Tumor Institute, 1515 Holcombe Boulevard, Box 117, Houston, TX (US)
• OSTI ID: 6465755
• Journal Information: Mol. Cell. Biol.; (United States), Vol. 8:7
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CELL DIFFERENTIATION
GENE REGULATION
GENE OPERONS
DNA SEQUENCING
MUSCLES
PHOSPHOTRANSFERASES
CREATINE
GENE REPRESSORS
GENES
ISOENZYMES
MICE
PHENOTYPE
SIMIAN VIRUS
SPECIFICITY
TRANSCRIPTION
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
ENZYMES
MAMMALS
MICROORGANISMS
NUCLEOPROTEINS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS-GROUP TRANSFERASES
PROTEINS
RODENTS
STRUCTURAL CHEMICAL ANALYSIS
TRANSFERASES
VERTEBRATES
VIRUSES
550200* - Biochemistry
550800 - Morphology