Influence of vitamin E on polyamine metabolism in ozone-exposed rat lungs
The influence of vitamin E (E) on lung polyamine metabolism of rats exposed to ozone (O/sub 3/) was examined. Rats fed diets either E-deficient or supplemented with 1000 IU E/kg were exposed to 0.5 +/- 0.05 ppm O/sub 3/ or filtered room air continuously for 5 days. They were then sacrificed and their lungs were analyzed for biochemical changes. Lung E content was strongly associated with the dietary level, and increased (36%, P less than 0.05) after O/sub 3/ exposure only in E-supplemented rats. Lung polyamine metabolism was not affected in the air-control rats by E level, but increased after O/sub 3/ exposure in both dietary groups. The activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase were elevated above air controls. However, the increases were significant only for E-deficient rats when compared to E-supplemented rats. After O/sub 3/ exposure, putrescine increased significantly in both dietary groups; spermidine increased but was significantly higher only in the E-deficient group; and spermine remained unchanged in both dietary groups. Elevated E content of supplemented rat lungs after O/sub 3/ exposure may represent its mobilization under oxidant stress. Increased polyamine metabolism of E-deficient rats suggests either a greater sensitivity to injury by O/sub 3/ or a possible antioxidant function for polyamines compensating for E deficiency.
- Research Organization:
- Univ. of California, Los Angeles
- OSTI ID:
- 6465219
- Journal Information:
- Arch. Biochem. Biophys.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AMINES
METABOLISM
OZONE
TOXICITY
VITAMIN E
BIOLOGICAL EFFECTS
DECARBOXYLASES
LUNGS
PUTRESCINE
RATS
SPERMIDINE
SPERMINE
ANIMALS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
ENZYMES
LYASES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
VITAMINS
560300* - Chemicals Metabolism & Toxicology