Renal handling of amino acid /sup 99m/technetium chelates
Four amino acids--alanine, 2,3-diaminopropionic acid, cystine, and cystein--and also one diamine, ethylenediamine, were chelated with /sup 99m/-technetium (/sup 99m/Tc), and their renal excretion patterns were studied in rabbits in the presence and absence of two renal tubular transport inhibitors, probenecid and 2,4-dinitrophenol. From the depression of renal excretion for the first three amino acid chelates, in the presence of the inhibitors, a renal tubular excretory pathway of elimination was suggested for these compounds. The renal excretions of /sup 99m/Tc-cystein and /sup 99m/Tc-ethylenediamine however, remained undepressed under similar experimental conditions. An explanation of these observations was forwarded from the possible chemical structures of these chelates.
- Research Organization:
- Indian Institute of Chemical Biology, Calcutta
- OSTI ID:
- 6459055
- Journal Information:
- J. Inorg. Biochem.; (United States), Vol. 34:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparison of a new Tc-99m renal function agent, Tc-99m mercaptoacetyltriglycine, with I-131 OIH
Mechanism of renal concentration of technetium-99m glucoheptonate
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
AMINES
RENAL CLEARANCE
AMINO ACIDS
NITROPHENOL
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CHELATES
ISOMERIC NUCLEI
KIDNEYS
METABOLISM
RABBITS
TECHNETIUM 99
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CLEARANCE
COMPLEXES
DISTRIBUTION
EXCRETION
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NITRO COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
RADIOISOTOPES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques