Physiological significance of benzo(. cap alpha. )pyrene adsorbed to carbon blacks: elution studies, AHH determinations

Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668191420152· OSTI ID:6453617

Buddingh, F; Bailey, M J; Wells, B; Haesemeyer, J

Desorption of benzo(..cap alpha..)pyrene from commercial carbon blacks by tissue fluids in vitro is compared to arylhydrocarbon hydroxylase induction in mice at three levels of carbon black exposure. Less than 0.005% of the adsorbed benzo(..cap alpha..)pyrene content determined by soxhlet extraction in toluene is eluted by human plasma, swine serum, swine lung homogenate and swine lung washings. Statistically significant differences in elution efficiency are observed for the various tissue fluids and carbon blacks. There is no detectable increase in AHH level in mouse lung or liver tissues even at the highest carbon black exposure and consumption rate of 1g/g bdywt/year.

• Research Organization: Texas Tech Univ., Lubbock
• OSTI ID: 6453617
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Vol. 42:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BENZOPYRENE
TOXICITY
CARBON BLACK
BIOASSAY
BLOOD PLASMA
BLOOD SERUM
BODY FLUIDS
DOSE-RESPONSE RELATIONSHIPS
ELUTRIATION
HYDROLASES
IN VITRO
INHALATION
LIVER
LUNGS
METABOLISM
MICE
PATHOLOGY
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
RETENTION
TISSUE DISTRIBUTION
TISSUES
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BODY
CARBON
CHEMICAL ANALYSIS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
ENZYMES
GLANDS
HYDROCARBONS
INTAKE
MAMMALS
MATERIALS
NONMETALS
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550900 - Pathology