Tissue metallothionein: dietary interaction of cadmium and zinc with copper, mercury, and silver

Journal Article · Sun Mar 01 00:00:00 EST 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530000· OSTI ID:6453376

Oh, S H; Whanger, P D; Deagen, J T

The interaction of dietary Cd and An with Cu, Hg, and Ag in relation to tissue metallothionein (MT) was studied with rats. Dietary Cd was found to increase the deposition of Cu and Ag in liver and kidney MT. Cd also caused accumulation of Hg in liver MT but depletion of Hg in kidney MT. In contrast to Cd, high dietary levels of Zn had no influence on the deposition of these metals in MT when they were included in the diet. When Zn was fed in the diet and Cu, Cd, Hg, and Ag were injected into rats, Zn caused increased deposition of these metals in MT, suggesting an interaction at the intestinal level.

• Research Organization: Oregon State Univ., Corvallis
• OSTI ID: 6453376
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 7:3-4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BIOLOGICAL EFFECTS
METABOLISM
COPPER
BIOLOGICAL ACCUMULATION
MERCURY
SILVER
ZINC
DIET
KIDNEYS
LIVER
METALLOTHIONEIN
RATS
ANIMALS
BODY
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
MAMMALS
METALLOPROTEINS
METALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)