Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated dibenzofuran-free Aroclor 1254 on diethylnitrosamine-induced tumorigenesis in the rat
The hepatic tumor-promoting activity of a commercial polychlorinated biphenyl mixture, Aroclor 1254 (AR 1254), with and without its intrinsic polychlorinated dibenzofuran (PCDF) impurities, was investigated. Male Sprague-Dawley noninbred albino rats were treated with 66 ..mu..g diethylnitrosamine (DENA)/ml drinking water for 5 weeks and subsequently given a control diet or a diet supplemented (100 ppM for 18 wk) with either AR 1254 or AR 1254 from which the PCDF moieties were removed (AR 1254-PCDF). Of those animals receiving DENA alone, 16% exhibited hepatocellular carcinomas. Of those rats treated with DENA followed by administration of AR 1254 or AR 1254-PCDF, 64 or 84%, respectively, developed hepatocellular carcinomas. Thus promotion with either AR 1254 or AR 1254-PCDF significantly (P < 0.05) increased the incidence of DENA-initiated hepatocellular carcinomas. Administration of AR 1254 or AR 1254-PCDF alone did not include hepatic tumors. Therefore, PCDF impurities were not necessary for the promoting activity of AR 1254.
- Research Organization:
- Univ. of Wisconsin, Madison
- OSTI ID:
- 6441821
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 66:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AROMATICS
TUMOR PROMOTERS
NITROSO COMPOUNDS
CARCINOGENS
ORGANIC CHLORINE COMPOUNDS
AMINES
BIOLOGICAL EFFECTS
CARCINOMAS
DRINKING WATER
LIVER
ORAL ADMINISTRATION
RATS
ANIMALS
BODY
DIGESTIVE SYSTEM
DISEASES
GLANDS
HYDROGEN COMPOUNDS
MAMMALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PROMOTERS
RODENTS
VERTEBRATES
WATER
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)