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Title: Vitamins as radioprotectors in vivo. I. Protection by vitamin C against internal radionuclides in mouse testes: Implications to the mechanism of damage caused by the Auger effect

Abstract

The potential of vitamin C, an antioxidant, to protect the radiosensitive spermatogonial cells in mouse testes against the effects of chronic irradiation by radionuclides incorporated into tissue was investigated. Interestingly, when injected intratesticularly, a small and nontoxic amount of vitamin C (1.5 [mu]g in 3 [mu]l saline) protected the spermatogonia against the damage associated with high-LET radiation caused by Auger electrons from similarly administered 5-([sup 125]I)-iodo-2[prime]-deoxyuridine ([sup 125]IdU). A dose modification factor (DMF) of 2.3 was obtained. In contrast, no protection was observed when [sup 210]Po, an [alpha]-particle emitter, was administered similarly. These findings suggest that the mechanism of action of the Auger effect is of an indirect nature, which is in contrast to the direct action generally believed to be responsible for biological damage caused by high-LET radiations. 31 refs., 4 figs., 1 tab.

Authors:
; ; ;  [1];  [2]
  1. (Univ. of Medicine and Dentistry of New Jersey, Newark, NJ (United States))
  2. (Univ. of Massachusetts, Amherst, MA (United States))
Publication Date:
OSTI Identifier:
6439940
Resource Type:
Journal Article
Journal Name:
Radiation Research; (United States)
Additional Journal Information:
Journal Volume: 137:3; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ASCORBIC ACID; RESPONSE MODIFYING FACTORS; IODODEOXYURIDINE; AUGER EFFECT; RADIOPROTECTIVE SUBSTANCES; BIOLOGICAL PATHWAYS; SPERMATOGONIA; RADIONUCLIDE KINETICS; CHRONIC IRRADIATION; LET; MICE; TESTES; VITAMINS; ANIMALS; ANTIMETABOLITES; AZINES; BODY; CHRONIC EXPOSURE; DRUGS; ENERGY TRANSFER; GAMETES; GERM CELLS; GONADS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IODOURACILS; IRRADIATION; MALE GENITALS; MAMMALS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RIBOSIDES; RODENTS; URACILS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 560160 - Radionuclide Effects, Kinetics, & Toxicology; 550200 - Biochemistry

Citation Formats

Narra, V.R., Harapanhalli, R.S., Howell, R.W., Rao, D.V., and Sastry, K.S.R. Vitamins as radioprotectors in vivo. I. Protection by vitamin C against internal radionuclides in mouse testes: Implications to the mechanism of damage caused by the Auger effect. United States: N. p., 1994. Web. doi:10.2307/3578715.
Narra, V.R., Harapanhalli, R.S., Howell, R.W., Rao, D.V., & Sastry, K.S.R. Vitamins as radioprotectors in vivo. I. Protection by vitamin C against internal radionuclides in mouse testes: Implications to the mechanism of damage caused by the Auger effect. United States. doi:10.2307/3578715.
Narra, V.R., Harapanhalli, R.S., Howell, R.W., Rao, D.V., and Sastry, K.S.R. Tue . "Vitamins as radioprotectors in vivo. I. Protection by vitamin C against internal radionuclides in mouse testes: Implications to the mechanism of damage caused by the Auger effect". United States. doi:10.2307/3578715.
@article{osti_6439940,
title = {Vitamins as radioprotectors in vivo. I. Protection by vitamin C against internal radionuclides in mouse testes: Implications to the mechanism of damage caused by the Auger effect},
author = {Narra, V.R. and Harapanhalli, R.S. and Howell, R.W. and Rao, D.V. and Sastry, K.S.R.},
abstractNote = {The potential of vitamin C, an antioxidant, to protect the radiosensitive spermatogonial cells in mouse testes against the effects of chronic irradiation by radionuclides incorporated into tissue was investigated. Interestingly, when injected intratesticularly, a small and nontoxic amount of vitamin C (1.5 [mu]g in 3 [mu]l saline) protected the spermatogonia against the damage associated with high-LET radiation caused by Auger electrons from similarly administered 5-([sup 125]I)-iodo-2[prime]-deoxyuridine ([sup 125]IdU). A dose modification factor (DMF) of 2.3 was obtained. In contrast, no protection was observed when [sup 210]Po, an [alpha]-particle emitter, was administered similarly. These findings suggest that the mechanism of action of the Auger effect is of an indirect nature, which is in contrast to the direct action generally believed to be responsible for biological damage caused by high-LET radiations. 31 refs., 4 figs., 1 tab.},
doi = {10.2307/3578715},
journal = {Radiation Research; (United States)},
issn = {0033-7587},
number = ,
volume = 137:3,
place = {United States},
year = {1994},
month = {3}
}