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Title: Evaluation of the potential carcinogenicity of chromium and hexavalent chromium compounds. Final report

Abstract

Hexavalent chromium compounds are human carcinogens, classified as weight-of-evidence Group A (based on chromate production workers and animal data which indicates that inhaled hexavalent chromium compounds are carcinogenic) under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is Sufficient. As stated in the U.S. EPA Health Assessment Document on chromium and compounds, metallic chromium is biologically inert and has not been reported to produce tumors in man or animal models. The no data are available on the carcinogenicity of metallic chromium. The potency factor (F) for hexavalent chromium is estimated to be 389/(mg/kg/day) (based on epidemiological data for the inhalation of hexavalent chromium by chromate workers), placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, all of the hexavalent chromium compounds are assigned a HIGH hazard ranking for the purposes of RQ adjustment.

Publication Date:
Research Org.:
Syracuse Research Corp., NY (United States)
OSTI Identifier:
6428381
Report Number(s):
PB-93-185148/XAB
CNN: EPA-68-03-3112; EPA-68-03-3182
Resource Type:
Technical Report
Resource Relation:
Other Information: See also PB--85-115905
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 29 ENERGY PLANNING, POLICY AND ECONOMY; CARCINOGENS; RISK ASSESSMENT; CHROMIUM COMPOUNDS; TOXICITY; ANIMALS; CHROMIUM; DOSE-RESPONSE RELATIONSHIPS; EPIDEMIOLOGY; HUMAN POPULATIONS; INHALATION; INORGANIC COMPOUNDS; PRODUCTION; REGULATORY GUIDES; TASK SCHEDULING; US EPA; WEIGHT; DATA PROCESSING; DOCUMENT TYPES; ELEMENTS; INTAKE; METALS; NATIONAL ORGANIZATIONS; POPULATIONS; PROCESSING; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS; US ORGANIZATIONS; 560300* - Chemicals Metabolism & Toxicology; 290300 - Energy Planning & Policy- Environment, Health, & Safety

Citation Formats

. Evaluation of the potential carcinogenicity of chromium and hexavalent chromium compounds. Final report. United States: N. p., 1988. Web.
. Evaluation of the potential carcinogenicity of chromium and hexavalent chromium compounds. Final report. United States.
. 1988. "Evaluation of the potential carcinogenicity of chromium and hexavalent chromium compounds. Final report". United States.
@article{osti_6428381,
title = {Evaluation of the potential carcinogenicity of chromium and hexavalent chromium compounds. Final report},
author = {},
abstractNote = {Hexavalent chromium compounds are human carcinogens, classified as weight-of-evidence Group A (based on chromate production workers and animal data which indicates that inhaled hexavalent chromium compounds are carcinogenic) under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is Sufficient. As stated in the U.S. EPA Health Assessment Document on chromium and compounds, metallic chromium is biologically inert and has not been reported to produce tumors in man or animal models. The no data are available on the carcinogenicity of metallic chromium. The potency factor (F) for hexavalent chromium is estimated to be 389/(mg/kg/day) (based on epidemiological data for the inhalation of hexavalent chromium by chromate workers), placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, all of the hexavalent chromium compounds are assigned a HIGH hazard ranking for the purposes of RQ adjustment.},
doi = {},
url = {https://www.osti.gov/biblio/6428381}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jun 01 00:00:00 EDT 1988},
month = {Wed Jun 01 00:00:00 EDT 1988}
}

Technical Report:
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