Effects of ammonia on selected hepatic microsomal enzyme activity in mice

Journal Article · Mon Jul 01 00:00:00 EDT 1985 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01636474· OSTI ID:6425439

Kapeghian, J C; Jones, A B; Waters, I W

Atmospheric ammonia (NH/sub 3/) is produced by a number of industrial sources however it is the biological action of urease-containing bacteria upon urine and fecal waste products that is responsible for producing NH/sub 3/ in laboratory animal facilities. Since NH/sub 3/ is a primary irritant, studies emphasizing the pulmonary toxicity of both acute and repeated exposures have appeared. Since the mouse has proven to be a sensitive animal model for use in NH/sub 3/ toxicity studies and work in the rat has produced only minimal microsomal changes, the present study was undertaken to determine whether acute or repeated exposure to NH/sub 3/ gas inhibits selected microsomal enzyme activity in the mouse.

• Research Organization: Univ. of Mississippi, University
• OSTI ID: 6425439
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 35:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMMONIA
BIOLOGICAL EFFECTS
INHALATION
ENZYME ACTIVITY
INHIBITION
MICROSOMES
AIR POLLUTION
EXPOSURE CHAMBERS
HYDROXYLASES
LIVER
LYASES
MICE
ANIMALS
BODY
CELL CONSTITUENTS
DIGESTIVE SYSTEM
ENZYMES
GLANDS
HYDRIDES
HYDROGEN COMPOUNDS
INTAKE
MAMMALS
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
ORGANOIDS
ORGANS
OXIDOREDUCTASES
POLLUTION
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)