Synthesis and characterization of organohydrazino complexes of technetium, rhenium, and molybdenum with the [M({eta}{sup 1}-H{sub x}NNR)({eta}{sup 2}-H{sub y}NNR)] core and their relationship to radiolabeled organohydrazine-derivatives chemotactic peptides with diagnostic applications

Rose, D J; Maresca, K P; Nicholson, T

doi:10.1021/ic970352f

Title: Synthesis and characterization of organohydrazino complexes of technetium, rhenium, and molybdenum with the [M({eta}{sup 1}-H{sub x}NNR)({eta}{sup 2}-H{sub y}NNR)] core and their relationship to radiolabeled organohydrazine-derivatives chemotactic peptides with diagnostic applications

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Abstract

In this paper, the authors present the details of the preparation of the imaging agent and its imaging properties. In order to define some structural possibilities for the coordination chemistry relevant to these reagents, they also present the results of investigations of the syntheses and structures of Tc, Mo, and Re complexes with hydrazinopyridine, which not only establish the formation of the robust unit, but also implicate chelate formation through the pyridine nitrogen as a significant structural determinant. The structures of the parent (bis)hydrazino-trichlorometalate core compounds are presented, allowing analysis of structural changes that occur when (2) protonation sites on the ligand change, (2) a different metal is employed, and (3) a different chelating hydrazine is utilized. The structures of the thiolate substitution products of these parent compounds are also presented. These derivatives demonstrate that rhenium and technetium have analogous substitution chemistry.

Authors:

Rose, D J; Maresca, K P ^[1]; Nicholson, T ^[2]

Syracuse Univ., NY (United States). Dept. of Chemistry
Massachusetts Inst. of Tech., Cambridge, MA (United States). Chemistry Dept.; and others

Publication Date:: Mon Jun 01 00:00:00 EDT 1998

Sponsoring Org.:: USDOE, Washington, DC (United States)

OSTI Identifier:: 642394

Resource Type:: Journal Article

Journal Name:: Inorganic Chemistry

Additional Journal Information:: Journal Volume: 37; Journal Issue: 11; Other Information: PBD: 1 Jun 1998

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; TECHNETIUM COMPLEXES; RHENIUM COMPLEXES; MOLYBDENUM COMPLEXES; SYNTHESIS; PYRIDINES; RADIOPHARMACEUTICALS; TECHNETIUM 99; HYDRAZINE; MOLECULAR STRUCTURE; EXPERIMENTAL DATA

Citation Formats


                    Rose, D J, Maresca, K P, and Nicholson, T. Synthesis and characterization of organohydrazino complexes of technetium, rhenium, and molybdenum with the [M({eta}{sup 1}-H{sub x}NNR)({eta}{sup 2}-H{sub y}NNR)] core and their relationship to radiolabeled organohydrazine-derivatives chemotactic peptides with diagnostic applications.  United States: N. p., 1998. 
        Web.  doi:10.1021/ic970352f.

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                    Rose, D J, Maresca, K P, & Nicholson, T. Synthesis and characterization of organohydrazino complexes of technetium, rhenium, and molybdenum with the [M({eta}{sup 1}-H{sub x}NNR)({eta}{sup 2}-H{sub y}NNR)] core and their relationship to radiolabeled organohydrazine-derivatives chemotactic peptides with diagnostic applications.  United States.  https://doi.org/10.1021/ic970352f

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                    Rose, D J, Maresca, K P, and Nicholson, T. 1998.  
        "Synthesis and characterization of organohydrazino complexes of technetium, rhenium, and molybdenum with the [M({eta}{sup 1}-H{sub x}NNR)({eta}{sup 2}-H{sub y}NNR)] core and their relationship to radiolabeled organohydrazine-derivatives chemotactic peptides with diagnostic applications".  United States.  https://doi.org/10.1021/ic970352f.

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@article{osti_642394,

  title        = {Synthesis and characterization of organohydrazino complexes of technetium, rhenium, and molybdenum with the [M({eta}{sup 1}-H{sub x}NNR)({eta}{sup 2}-H{sub y}NNR)] core and their relationship to radiolabeled organohydrazine-derivatives chemotactic peptides with diagnostic applications},

  author       = {Rose, D J and Maresca, K P and Nicholson, T},

  abstractNote = {In this paper, the authors present the details of the preparation of the imaging agent and its imaging properties. In order to define some structural possibilities for the coordination chemistry relevant to these reagents, they also present the results of investigations of the syntheses and structures of Tc, Mo, and Re complexes with hydrazinopyridine, which not only establish the formation of the robust unit, but also implicate chelate formation through the pyridine nitrogen as a significant structural determinant. The structures of the parent (bis)hydrazino-trichlorometalate core compounds are presented, allowing analysis of structural changes that occur when (2) protonation sites on the ligand change, (2) a different metal is employed, and (3) a different chelating hydrazine is utilized. The structures of the thiolate substitution products of these parent compounds are also presented. These derivatives demonstrate that rhenium and technetium have analogous substitution chemistry.},

  doi          = {10.1021/ic970352f},

  url          = {https://www.osti.gov/biblio/642394},
  journal      = {Inorganic Chemistry},
number       = 11,

  volume       = 37,

  place        = {United States},

  year         = {Mon Jun 01 00:00:00 EDT 1998},

  month        = {Mon Jun 01 00:00:00 EDT 1998}

}

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