skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Tissue characterization of brain tumors during and after pion radiation therapy

Abstract

Negative Pi-mesons (pions) are applied at the Paul Scherrer Institute in the radiotherapy of highly malignant gliomas using a dose escalation program. The therapy effects of 7 randomly selected patients were followed up by 62 MRI examinations. The quantification of the effects is based on the relaxation times T1 and T2, which are acquired by a new designed multi-echo multiple saturation recovery imaging technique. As a summary of the results, roughly two reaction types are observed. For both types the relaxation times increase up to two to three months after the radiation therapy. Then in one type (two patients) the T1 and T2 values of the tumors, and of the edemas surrounding the tumors, further increase, indicating an unfavorable prognosis. In the other type (five patients) the relaxation times drop down towards, or even below, their initial values, reflecting the onset of the reparation processes in the tissue. This later behavior reflects an at least temporary control of the disease; that is, the short term prognosis for these patients is more favorable. It further can be concluded, with respect to our MR parameters, that the radiotolerance of healthy brain tissue is much higher than that of malignant glioma tissue, despitemore » the fact that these tumors are very seldom definitively radiosensible.« less

Authors:
; ; ; ;  [1]
  1. Univ. of Zurich (Switzerland)
Publication Date:
OSTI Identifier:
6420477
Resource Type:
Journal Article
Journal Name:
Magnetic Resonance Imaging; (USA)
Additional Journal Information:
Journal Volume: 8:4; Journal ID: ISSN 0730-725X
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; BIOLOGICAL RADIATION EFFECTS; GLIOMAS; RADIOTHERAPY; PIONS; DOSE-RESPONSE RELATIONSHIPS; NMR IMAGING; PATIENTS; POST-IRRADIATION EXAMINATION; SIDE EFFECTS; BIOLOGICAL EFFECTS; BODY; BOSONS; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTARY PARTICLES; HADRONS; MEDICINE; MESONS; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; PSEUDOSCALAR MESONS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man

Citation Formats

Boesiger, P, Greiner, R, Schoepflin, R E, Kann, R, and Kuenzi, U. Tissue characterization of brain tumors during and after pion radiation therapy. United States: N. p., 1990. Web. doi:10.1016/0730-725X(90)90057-9.
Boesiger, P, Greiner, R, Schoepflin, R E, Kann, R, & Kuenzi, U. Tissue characterization of brain tumors during and after pion radiation therapy. United States. https://doi.org/10.1016/0730-725X(90)90057-9
Boesiger, P, Greiner, R, Schoepflin, R E, Kann, R, and Kuenzi, U. 1990. "Tissue characterization of brain tumors during and after pion radiation therapy". United States. https://doi.org/10.1016/0730-725X(90)90057-9.
@article{osti_6420477,
title = {Tissue characterization of brain tumors during and after pion radiation therapy},
author = {Boesiger, P and Greiner, R and Schoepflin, R E and Kann, R and Kuenzi, U},
abstractNote = {Negative Pi-mesons (pions) are applied at the Paul Scherrer Institute in the radiotherapy of highly malignant gliomas using a dose escalation program. The therapy effects of 7 randomly selected patients were followed up by 62 MRI examinations. The quantification of the effects is based on the relaxation times T1 and T2, which are acquired by a new designed multi-echo multiple saturation recovery imaging technique. As a summary of the results, roughly two reaction types are observed. For both types the relaxation times increase up to two to three months after the radiation therapy. Then in one type (two patients) the T1 and T2 values of the tumors, and of the edemas surrounding the tumors, further increase, indicating an unfavorable prognosis. In the other type (five patients) the relaxation times drop down towards, or even below, their initial values, reflecting the onset of the reparation processes in the tissue. This later behavior reflects an at least temporary control of the disease; that is, the short term prognosis for these patients is more favorable. It further can be concluded, with respect to our MR parameters, that the radiotolerance of healthy brain tissue is much higher than that of malignant glioma tissue, despite the fact that these tumors are very seldom definitively radiosensible.},
doi = {10.1016/0730-725X(90)90057-9},
url = {https://www.osti.gov/biblio/6420477}, journal = {Magnetic Resonance Imaging; (USA)},
issn = {0730-725X},
number = ,
volume = 8:4,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}