Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone

Journal Article · Wed Feb 01 00:00:00 EST 1989 · Cancer Res.; (United States)

OSTI ID:6403255

van Alphen, M M; van de Kant, H J; de Rooij, D G

In adult rhesus monkeys a two- to threefold increase in the number of spermatogonia was found at Day 75 after 1 Gy of X-irradiation when the animals were pretreated with two intramuscular injections of follicle-stimulating hormone (FSH) each day. Also the percentage of cross-sections of seminiferous tubules showing spermatogonia (repopulation index) was much higher when FSH was given before irradiation. At 75 days postirradiation the repopulation index was 39 +/- 10% after irradiation alone and 81 +/- 11% when FSH pretreatment was applied. The pretreatment with two injections of FSH each day during 16 days caused an increase in the number of proliferating A spermatogonia. In view of earlier results in the mouse, where proliferating spermatogonial stem cells appeared more radioresistant than quiescent ones, it is suggested that the protective effects of FSH treatment are caused by the increase in the proliferative activity of the A spermatogonia and consequently of the spermatogonial stem cells. The results indicate that in the rhesus monkey the maximal protective effect of FSH is reached after a period of treatment between 7 and 16 days.

• Research Organization: State Univ. of Utrecht (Netherlands)
• OSTI ID: 6403255
• Journal Information: Cancer Res.; (United States), Vol. 49:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FSH
RADIOSENSITIVITY EFFECTS
SPERMATOGONIA
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
MONKEYS
RADIATION PROTECTION
SPERMATOGENESIS
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
ELECTROMAGNETIC RADIATION
GAMETES
GAMETOGENESIS
GERM CELLS
GONADOTROPINS
HORMONES
IONIZING RADIATIONS
MAMMALS
PEPTIDE HORMONES
PITUITARY HORMONES
PRIMATES
RADIATION EFFECTS
RADIATIONS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals