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Title: Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone

Abstract

In adult rhesus monkeys a two- to threefold increase in the number of spermatogonia was found at Day 75 after 1 Gy of X-irradiation when the animals were pretreated with two intramuscular injections of follicle-stimulating hormone (FSH) each day. Also the percentage of cross-sections of seminiferous tubules showing spermatogonia (repopulation index) was much higher when FSH was given before irradiation. At 75 days postirradiation the repopulation index was 39 +/- 10% after irradiation alone and 81 +/- 11% when FSH pretreatment was applied. The pretreatment with two injections of FSH each day during 16 days caused an increase in the number of proliferating A spermatogonia. In view of earlier results in the mouse, where proliferating spermatogonial stem cells appeared more radioresistant than quiescent ones, it is suggested that the protective effects of FSH treatment are caused by the increase in the proliferative activity of the A spermatogonia and consequently of the spermatogonial stem cells. The results indicate that in the rhesus monkey the maximal protective effect of FSH is reached after a period of treatment between 7 and 16 days.

Authors:
; ;
Publication Date:
Research Org.:
State Univ. of Utrecht (Netherlands)
OSTI Identifier:
6403255
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cancer Res.; (United States); Journal Volume: 49:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FSH; RADIOSENSITIVITY EFFECTS; SPERMATOGONIA; BIOLOGICAL RADIATION EFFECTS; CELL PROLIFERATION; MONKEYS; RADIATION PROTECTION; SPERMATOGENESIS; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; ELECTROMAGNETIC RADIATION; GAMETES; GAMETOGENESIS; GERM CELLS; GONADOTROPINS; HORMONES; IONIZING RADIATIONS; MAMMALS; PEPTIDE HORMONES; PITUITARY HORMONES; PRIMATES; RADIATION EFFECTS; RADIATIONS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

van Alphen, M.M., van de Kant, H.J., and de Rooij, D.G. Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone. United States: N. p., 1989. Web.
van Alphen, M.M., van de Kant, H.J., & de Rooij, D.G. Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone. United States.
van Alphen, M.M., van de Kant, H.J., and de Rooij, D.G. 1989. "Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone". United States. doi:.
@article{osti_6403255,
title = {Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone},
author = {van Alphen, M.M. and van de Kant, H.J. and de Rooij, D.G.},
abstractNote = {In adult rhesus monkeys a two- to threefold increase in the number of spermatogonia was found at Day 75 after 1 Gy of X-irradiation when the animals were pretreated with two intramuscular injections of follicle-stimulating hormone (FSH) each day. Also the percentage of cross-sections of seminiferous tubules showing spermatogonia (repopulation index) was much higher when FSH was given before irradiation. At 75 days postirradiation the repopulation index was 39 +/- 10% after irradiation alone and 81 +/- 11% when FSH pretreatment was applied. The pretreatment with two injections of FSH each day during 16 days caused an increase in the number of proliferating A spermatogonia. In view of earlier results in the mouse, where proliferating spermatogonial stem cells appeared more radioresistant than quiescent ones, it is suggested that the protective effects of FSH treatment are caused by the increase in the proliferative activity of the A spermatogonia and consequently of the spermatogonial stem cells. The results indicate that in the rhesus monkey the maximal protective effect of FSH is reached after a period of treatment between 7 and 16 days.},
doi = {},
journal = {Cancer Res.; (United States)},
number = ,
volume = 49:3,
place = {United States},
year = 1989,
month = 2
}