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Title: Contribution of polycyclic aromatic hydrocarbons and polar polycyclic aromatic compounds to the carcinogenic impact of flue gas condensate from coal-fired residential furnaces evaluated by implantation into the rat lung

Abstract

For identification of the substances chiefly responsible for the carcinogenic action of the emission condensate from coal-fired residential furnaces, the implantation method was used as a carcinogen-specific bioassay for comparison of the carcinogenic effect of various fractions with that of a total sample of flue gas condensate tested in 2 or 3 different doses. After implantation into the lungs of Osborne-Mendel rats, the condensate from coal-fired residential furnaces, a fraction containing polycyclic aromatic hydrocarbons (PAHs) and thiaarenes (sulfur-containing polycyclic aromatic compounds (S-PACs)) with 4-7 rings, as well as fraction containing more polar polycyclic aromatic compounds (PACs) and PAHs with higher molecular weight, induced lung carcinomas and sarcomas. According to probit analysis, the fraction containing PAHs plus S-PACs with 4-7 rings accounted for about 68.2% of the total carcinogenicity of flue gas condensate, whereas the fraction containing more polar PACs and higher PAHs accounted for about 54.6%. All other fractions, such as nonaromatic compounds and PACs with 2 and 3 rings, constituting about 70% of the weight of the total condensate, seemed not to be carcinogenic. Only 1.4% of the total carcinogenicity of the flue gas condensate was found to be attributable to the amount of benzo(a)pyrene (CAS: 50-32-8) present inmore » the condensate (1.14 mg/g condensate). The contribution of more than 100% of both active fractions to the total carcinogenicity (68.2 and 54.6%) may suggest an interrelation of the fractions.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Biochemical Institute for Environmental Carcinogens, Grosshansdorf, Germany, F.R.
OSTI Identifier:
6391975
Resource Type:
Journal Article
Journal Name:
J. Natl. Cancer Inst.; (United States)
Additional Journal Information:
Journal Volume: 5
Country of Publication:
United States
Language:
English
Subject:
01 COAL, LIGNITE, AND PEAT; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BENZOPYRENE; CARCINOGEN SCREENING; FLUE GAS; TOXICITY; LUNGS; CARCINOMAS; SARCOMAS; POLYCYCLIC AROMATIC HYDROCARBONS; AIR POLLUTION; CARCINOGENS; COAL; DOSE-RESPONSE RELATIONSHIPS; RATS; ANIMALS; AROMATICS; BODY; CARBONACEOUS MATERIALS; CONDENSED AROMATICS; DISEASES; ENERGY SOURCES; FOSSIL FUELS; FUELS; GASEOUS WASTES; HYDROCARBONS; MAMMALS; MATERIALS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; POLLUTION; RESPIRATORY SYSTEM; RODENTS; SCREENING; VERTEBRATES; WASTES; 016000* - Coal, Lignite, & Peat- Health & Safety; 560300 - Chemicals Metabolism & Toxicology

Citation Formats

Grimmer, G, Brune, H, Deutsch-Wenzel, R, Dettbarn, G, and Misfeld, J. Contribution of polycyclic aromatic hydrocarbons and polar polycyclic aromatic compounds to the carcinogenic impact of flue gas condensate from coal-fired residential furnaces evaluated by implantation into the rat lung. United States: N. p., 1987. Web.
Grimmer, G, Brune, H, Deutsch-Wenzel, R, Dettbarn, G, & Misfeld, J. Contribution of polycyclic aromatic hydrocarbons and polar polycyclic aromatic compounds to the carcinogenic impact of flue gas condensate from coal-fired residential furnaces evaluated by implantation into the rat lung. United States.
Grimmer, G, Brune, H, Deutsch-Wenzel, R, Dettbarn, G, and Misfeld, J. Fri . "Contribution of polycyclic aromatic hydrocarbons and polar polycyclic aromatic compounds to the carcinogenic impact of flue gas condensate from coal-fired residential furnaces evaluated by implantation into the rat lung". United States.
@article{osti_6391975,
title = {Contribution of polycyclic aromatic hydrocarbons and polar polycyclic aromatic compounds to the carcinogenic impact of flue gas condensate from coal-fired residential furnaces evaluated by implantation into the rat lung},
author = {Grimmer, G and Brune, H and Deutsch-Wenzel, R and Dettbarn, G and Misfeld, J},
abstractNote = {For identification of the substances chiefly responsible for the carcinogenic action of the emission condensate from coal-fired residential furnaces, the implantation method was used as a carcinogen-specific bioassay for comparison of the carcinogenic effect of various fractions with that of a total sample of flue gas condensate tested in 2 or 3 different doses. After implantation into the lungs of Osborne-Mendel rats, the condensate from coal-fired residential furnaces, a fraction containing polycyclic aromatic hydrocarbons (PAHs) and thiaarenes (sulfur-containing polycyclic aromatic compounds (S-PACs)) with 4-7 rings, as well as fraction containing more polar polycyclic aromatic compounds (PACs) and PAHs with higher molecular weight, induced lung carcinomas and sarcomas. According to probit analysis, the fraction containing PAHs plus S-PACs with 4-7 rings accounted for about 68.2% of the total carcinogenicity of flue gas condensate, whereas the fraction containing more polar PACs and higher PAHs accounted for about 54.6%. All other fractions, such as nonaromatic compounds and PACs with 2 and 3 rings, constituting about 70% of the weight of the total condensate, seemed not to be carcinogenic. Only 1.4% of the total carcinogenicity of the flue gas condensate was found to be attributable to the amount of benzo(a)pyrene (CAS: 50-32-8) present in the condensate (1.14 mg/g condensate). The contribution of more than 100% of both active fractions to the total carcinogenicity (68.2 and 54.6%) may suggest an interrelation of the fractions.},
doi = {},
journal = {J. Natl. Cancer Inst.; (United States)},
number = ,
volume = 5,
place = {United States},
year = {1987},
month = {5}
}