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Title: Bis-(2-ethylhexyl) phthalate, an ubiquitous environmental contaminant

Abstract

Bis-(2-ethylhexyl) phthalate (DEHP) is the most commonly used plasticizing agent for the widely used plastic polyvinylchloride (PVC). Consequently, this compound is found everywhere in the environment of civilization, where it is in frequent contact with every person. Blood storage bags and tubing, food wrappers, and many children's toys contain appreciable amounts of DEHP. Given this frequency of exposure, the toxic potential of the compound has become a major concern. Many workers have demonstrated its exceedingly low acute toxicity, while results from chronic exposure studies have been mixed. However, in 1982 the National Toxicology Program reported a significantly increased incidence of hepatocellular carcinoma in rats and mice exposed to high doses of DEHP over a period of two years. The significance of these studies remains in question. Bis-(2-ethylhexyl) phthalate is metabolized extensively by mammals, but reports of the direct study of the toxic effects of its metabolites are few. Efficient methods for analysis of biological samples for DEHP are available, but they are complicated by the constant presence of this compound as a contaminant.

Authors:
; ;
Publication Date:
Research Org.:
Roger Williams General Hospital, Providence, RI
OSTI Identifier:
6390982
Alternate Identifier(s):
OSTI ID: 6390982
Resource Type:
Journal Article
Resource Relation:
Journal Name: Ann. Clin. Lab. Sci.; (United States); Journal Volume: 2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PHTHALATES; BIOLOGICAL EFFECTS; CARCINOGENS; CARCINOMAS; ENVIRONMENTAL EXPOSURE; LIVER; MICE; PLASTICIZERS; PVC; RATS; TERATOGENS; ANIMALS; BODY; CARBOXYLIC ACID SALTS; CHLORINATED ALIPHATIC HYDROCARBONS; DIGESTIVE SYSTEM; DISEASES; GLANDS; HALOGENATED ALIPHATIC HYDROCARBONS; MAMMALS; NEOPLASMS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC POLYMERS; ORGANS; POLYMERS; POLYVINYLS; RODENTS; VERTEBRATES 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)

Citation Formats

Griffiths, W.C., Camara, P., and Lerner, K.S. Bis-(2-ethylhexyl) phthalate, an ubiquitous environmental contaminant. United States: N. p., 1985. Web.
Griffiths, W.C., Camara, P., & Lerner, K.S. Bis-(2-ethylhexyl) phthalate, an ubiquitous environmental contaminant. United States.
Griffiths, W.C., Camara, P., and Lerner, K.S. Fri . "Bis-(2-ethylhexyl) phthalate, an ubiquitous environmental contaminant". United States.
@article{osti_6390982,
title = {Bis-(2-ethylhexyl) phthalate, an ubiquitous environmental contaminant},
author = {Griffiths, W.C. and Camara, P. and Lerner, K.S.},
abstractNote = {Bis-(2-ethylhexyl) phthalate (DEHP) is the most commonly used plasticizing agent for the widely used plastic polyvinylchloride (PVC). Consequently, this compound is found everywhere in the environment of civilization, where it is in frequent contact with every person. Blood storage bags and tubing, food wrappers, and many children's toys contain appreciable amounts of DEHP. Given this frequency of exposure, the toxic potential of the compound has become a major concern. Many workers have demonstrated its exceedingly low acute toxicity, while results from chronic exposure studies have been mixed. However, in 1982 the National Toxicology Program reported a significantly increased incidence of hepatocellular carcinoma in rats and mice exposed to high doses of DEHP over a period of two years. The significance of these studies remains in question. Bis-(2-ethylhexyl) phthalate is metabolized extensively by mammals, but reports of the direct study of the toxic effects of its metabolites are few. Efficient methods for analysis of biological samples for DEHP are available, but they are complicated by the constant presence of this compound as a contaminant.},
doi = {},
journal = {Ann. Clin. Lab. Sci.; (United States)},
number = ,
volume = 2,
place = {United States},
year = {Fri Mar 01 00:00:00 EST 1985},
month = {Fri Mar 01 00:00:00 EST 1985}
}