In vivo analysis of bone calcium by local neutron activation of the hand: results in normal and osteoporotic subjects

Journal Article · Thu Feb 01 00:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:6378623

Maziere, B; Kuntz, D; Comar, D; Ryckewaert, A

Mineral loss from bone can be measured accurately and reproducibly by neutron activation of the hand bones using a 5-min irradiation (10/sup 6/ n/cm/sup 2/-sec) with two 200-..mu..g sources of Cf-252. The hand dose is 7.5 rad equivalent and the dose to the rest of body is 1.5 mrem. Controls (132) and osteoporotic patients (45) were compared. Between ages 20 and 60 the control group showed a bone calcium concentration of 0.177 +- 0.025 g/cm/sup 3/, independent of age. Between 60 and 70 the content remained unchanged in men but declined in women to 0.15 +- 0.2 g/cm/sup 3/. In all age groups osteoporotic patients in general showed lower calcium content. Comparison of our findings (''Ca'') with estimates of bone mineral content obtained by photon absorptiometry (''BMC'') yields 0.07 Ca + 0.262 (r = 0.87). Activation analysis of hand bone appears more precise than BMC for the monitoring of bone-mineral loss in each individual and as a measure of treatment efficacy.

• Research Organization: Service Hospitalier Frederic Joliot, Orsay, France
• OSTI ID: 6378623
• Journal Information: J. Nucl. Med.; (United States), Vol. 20:2
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ANALYSIS
DIAGNOSTIC USES
BONE TISSUES
CALCIUM
HANDS
RADIATION DOSES
MAN
OSTEOPOROSIS
DIAGNOSIS
SKELETON
ABSORPTION SPECTROSCOPY
AGE DEPENDENCE
CALIFORNIUM 252
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
IN VIVO
ISOLATED VALUES
NEUTRON REACTIONS
PATIENTS
QUANTITY RATIO
SEX DEPENDENCE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH METALS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BARYON REACTIONS
BODY
BODY AREAS
CALIFORNIUM ISOTOPES
CHARGED-PARTICLE ACTIVATION
CONNECTIVE TISSUE
DATA
DATA FORMS
DISEASES
DOSES
ELEMENTS
EVEN-EVEN NUCLEI
HADRON REACTIONS
HEAVY NUCLEI
INFORMATION
ISOTOPES
LIMBS
MAMMALS
METALS
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUMERICAL DATA
ORGANS
PHOTON ACTIVATION ANALYSIS
PRIMATES
RADIOISOTOPES
SKELETAL DISEASES
SPECTROSCOPY
TISSUES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
400101* - Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures
550601 - Medicine- Unsealed Radionuclides in Diagnostics
560151 - Radiation Effects on Animals- Man