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Title: Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates

Patent ·
OSTI ID:6376251

The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject invention. The invention further provides methods of using the subject antibody for detecting an antigen of interest in a sample, for example, detecting a protein comprising an amino acid sequence of interest and detecting a nucleic acid molecule comprising a nucleic acid sequence of interest, detecting a polypeptide such as those expressed by infectious agents, fungi or parasites. 25 figs.

Sponsoring Organization:
USDOE; USDOE, Washington, DC (United States)
DOE Contract Number:
FG02-88ER60742
Assignee:
Columbia Univ., New York, NY (United States)
Patent Number(s):
US 5925532; A
Application Number:
PPN: US 8-898583
OSTI ID:
6376251
Resource Relation:
Patent File Date: 22 Jul 1997
Country of Publication:
United States
Language:
English