Carbon monoxide exposure of subjects with documented cardiac arrhythmias. Research report, August 1987-July 1991
The authors studied 30 subjects with well-documented coronary artery disease who had an average of at least 30 ventricular ectopic beats per hour over a 20-hour monitoring interval. Subjects were selected and enrolled in a randomized double-blind study; the carbon monoxide exposure was designed to result in 3% or 5% carboxyhemoglobin levels, as measured by gas chromatography. Total and repetitive ventricular arrhythmias were measured for four specific time intervals: (1) two hours before carbon monoxide exposure; (2) during the two-hour carbon monoxide exposure; (3) six hours after carbon monoxide exposure; and (4) approximately 10 hours after exposure, or the remaining recording interval on the Holter monitor. There was no increase in ventricular arrhythmia frequency after carbon monoxide exposure, regardless of the level of carboxyhemoglobin or the type of activity. During steady-state conditions at rest, the number of ventricular ectopic beats per hour was 115 + or - 153 (SD) for room air exposure (0.7% carboxyhemoglobin), 121 + or - 171 for the lower carbon monoxide exposure (3.2% carboxyhemoglobin), and 94 + or - 129 for the higher carbon monoxide exposure (5.1% carboxyhemoglobin). The frequency of complex ventricular ectopy was not altered at the levels of carbon monoxide studied. Secondary analysis of the impact of carbon monoxide on ventricular ectopic beat frequency stratified by baseline ejection fraction, baseline ventricular ectopic beat frequency, and exercise-induced ST-segment changes did not indicate an effect of carbon monoxide on ventricular arrhythmias. However, patients with symptomatic ventricular arrhythmias and symptomatic myocardial ischemia were excluded from the present study.
- Research Organization:
- Saint Louis Univ., MO (United States). School of Medicine
- OSTI ID:
- 6374196
- Report Number(s):
- PB-93-179943/XAB
- Country of Publication:
- United States
- Language:
- English
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