Models for DNA damage formation and repair in mammalian cells exposed to ionizing radiation
As the first stage in the development of a comprehensive explanation of radiation effects in mammalian cells, a general model for DNA damage formation and repair is described. This applies to events in mammalian cells exposed to ionizing radiation in a period before cell cycle progression has a significant effect. A large number of hypotheses can be formulated as specific cases of this general model by making the appropriate definition of damage types and repair mechanisms. Experimental data obtained by the analysis of changes in molecular weight of irradiated DNA are surveyed and used to construct five specific models for the formation and repair of DNA single- and double-strand breaks. The properties of these models are discussed and suggestions made for areas where new experiments could help to identify which are the important types of damage and repair mechanisms.
- Research Organization:
- Institut fur Angewandte Mathematik, Heidelberg, West Germany
- OSTI ID:
- 6373179
- Journal Information:
- Radiat. Res.; (United States), Vol. 92:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BIOLOGICAL RADIATION EFFECTS
MATHEMATICAL MODELS
STRAND BREAKS
RADIOINDUCTION
ANIMAL CELLS
BIOLOGICAL REPAIR
CHROMOSOMAL ABERRATIONS
DNA
DOSE-RESPONSE RELATIONSHIPS
ELECTRONS
ESCHERICHIA COLI
FIBROBLASTS
GAMMA RADIATION
LYMPHOCYTES
MOLECULAR WEIGHT
THEORETICAL DATA
X RADIATION
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
INFORMATION
IONIZING RADIATIONS
LEPTONS
LEUKOCYTES
MATERIALS
MICROORGANISMS
MUTATIONS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SOMATIC CELLS
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)
560121 - Radiation Effects on Cells- External Source- (-1987)