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Title: Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors

Abstract

Cultured human embryonal rhabdomyosarcoma cells express the basic fibroblast growth factor (bFGF) gene and they produced bFGF, which is apparently composed of two microheterogenous forms with M/sub r/s of 16,500 and 17,200, respectively. bFGF was purified by radioreceptor binding assays or cross-linking experiments. bFGF derived from the rhabdomyosarcoma cells stimulates their own proliferation and that of human or bovine vascular endothelial cells. It is conceivable that the rhabdomyosarcoma-derived bFGF stimulates the growth and neovascularization of human rhabdomyosarcomas and that it may thereby contribute to the development of these tumors.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Univ. of California Medical Center, San Francisco
OSTI Identifier:
6370953
Resource Type:
Journal Article
Journal Name:
Proc. Natl. Acad. Sci. U.S.A.; (United States)
Additional Journal Information:
Journal Volume: 84:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; PROTEINS; RADIORECEPTOR ASSAY; TUMOR CELLS; CELL PROLIFERATION; BLOOD VESSELS; CROSS-LINKING; FIBROBLASTS; GROWTH; IODINE 125; MAN; RHABDOMYOSARCOMAS; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; CHEMICAL REACTIONS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MYOSARCOMAS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; POLYMERIZATION; PRIMATES; RADIOISOTOPES; SARCOMAS; SOMATIC CELLS; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Schweigerer, L, Neufeld, G, Mergia, A, Abraham, J A, Fiddes, J C, and Gospodarowicz, D. Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors. United States: N. p., 1987. Web. doi:10.1073/pnas.84.3.842.
Schweigerer, L, Neufeld, G, Mergia, A, Abraham, J A, Fiddes, J C, & Gospodarowicz, D. Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors. United States. https://doi.org/10.1073/pnas.84.3.842
Schweigerer, L, Neufeld, G, Mergia, A, Abraham, J A, Fiddes, J C, and Gospodarowicz, D. 1987. "Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors". United States. https://doi.org/10.1073/pnas.84.3.842.
@article{osti_6370953,
title = {Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors},
author = {Schweigerer, L and Neufeld, G and Mergia, A and Abraham, J A and Fiddes, J C and Gospodarowicz, D},
abstractNote = {Cultured human embryonal rhabdomyosarcoma cells express the basic fibroblast growth factor (bFGF) gene and they produced bFGF, which is apparently composed of two microheterogenous forms with M/sub r/s of 16,500 and 17,200, respectively. bFGF was purified by radioreceptor binding assays or cross-linking experiments. bFGF derived from the rhabdomyosarcoma cells stimulates their own proliferation and that of human or bovine vascular endothelial cells. It is conceivable that the rhabdomyosarcoma-derived bFGF stimulates the growth and neovascularization of human rhabdomyosarcomas and that it may thereby contribute to the development of these tumors.},
doi = {10.1073/pnas.84.3.842},
url = {https://www.osti.gov/biblio/6370953}, journal = {Proc. Natl. Acad. Sci. U.S.A.; (United States)},
number = ,
volume = 84:3,
place = {United States},
year = {Sun Feb 01 00:00:00 EST 1987},
month = {Sun Feb 01 00:00:00 EST 1987}
}