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Title: Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation

Abstract

A study was undertaken by five radiation scientists to examine the feasibility of reducing the uncertainties in the estimation of risk due to protracted low doses of ionizing radiation. In addressing the question of feasibility, a review was made by the study group: of the cellular, molecular, and mammalian radiation data that are available; of the way in which altered oncogene properties could be involved in the loss of growth control that culminates in tumorigenesis; and of the progress that had been made in the genetic characterizations of several human and animal neoplasms. On the basis of this analysis, the study group concluded that, at the present time, it is feasible to mount a program of radiation research directed at the mechanism(s) of radiation-induced cancer with special reference to risk of neoplasia due to protracted, low doses of sparsely ionizing radiation. To implement a program of research, a review was made of the methods, techniques, and instruments that would be needed. This review was followed by a survey of the laboratories and institutions where scientific personnel and facilities are known to be available. A research agenda of the principal and broad objectives of the program is also discussed. 489 refs.,more » 21 figs., 14 tabs.« less

Authors:
; ; ;  [1];  [2]
+ Show Author Affiliations
  1. (Colorado State Univ., Fort Collins, CO (USA))
  2. (Science Applications International Corp., McLean, VA (USA))
Publication Date:
Research Org.:
Nuclear Regulatory Commission, Washington, DC (USA). Div. of Regulatory Applications; Science Applications International Corp., McLean, VA (USA)
Sponsoring Org.:
USNRC
OSTI Identifier:
6365510
Report Number(s):
NUREG/CR-5635
ON: TI91002485; TRN: 91-001626
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMALS; BIOLOGICAL RADIATION EFFECTS; HUMAN POPULATIONS; BIOLOGICAL EFFECTS; CARCINOGENESIS; FEASIBILITY STUDIES; GENETIC RADIATION EFFECTS; LOW DOSE IRRADIATION; MOLECULAR BIOLOGY; MUTAGENESIS; NEOPLASMS; ONCOGENES; ONCOGENIC TRANSFORMATIONS; RADIATION HAZARDS; RESEARCH PROGRAMS; CELL TRANSFORMATIONS; DISEASES; GENES; GENETIC EFFECTS; HAZARDS; HEALTH HAZARDS; IRRADIATION; PATHOGENESIS; POPULATIONS; RADIATION EFFECTS; 560100* - Biomedical Sciences, Applied Studies- Radiation Effects; 550600 - Medicine

Citation Formats

Elkind, M.M., Bedford, J., Benjamin, S.A., Waldren, C.A., and Gotchy, R.L. Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation. United States: N. p., 1990. Web. doi:10.2172/6365510.
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Elkind, M.M., Bedford, J., Benjamin, S.A., Waldren, C.A., & Gotchy, R.L. Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation. United States. doi:10.2172/6365510.
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Elkind, M.M., Bedford, J., Benjamin, S.A., Waldren, C.A., and Gotchy, R.L. Mon . "Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation". United States. doi:10.2172/6365510. https://www.osti.gov/servlets/purl/6365510.
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@article{osti_6365510,
title = {Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation},
author = {Elkind, M.M. and Bedford, J. and Benjamin, S.A. and Waldren, C.A. and Gotchy, R.L.},
abstractNote = {A study was undertaken by five radiation scientists to examine the feasibility of reducing the uncertainties in the estimation of risk due to protracted low doses of ionizing radiation. In addressing the question of feasibility, a review was made by the study group: of the cellular, molecular, and mammalian radiation data that are available; of the way in which altered oncogene properties could be involved in the loss of growth control that culminates in tumorigenesis; and of the progress that had been made in the genetic characterizations of several human and animal neoplasms. On the basis of this analysis, the study group concluded that, at the present time, it is feasible to mount a program of radiation research directed at the mechanism(s) of radiation-induced cancer with special reference to risk of neoplasia due to protracted, low doses of sparsely ionizing radiation. To implement a program of research, a review was made of the methods, techniques, and instruments that would be needed. This review was followed by a survey of the laboratories and institutions where scientific personnel and facilities are known to be available. A research agenda of the principal and broad objectives of the program is also discussed. 489 refs., 21 figs., 14 tabs.},
doi = {10.2172/6365510},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Oct 01 00:00:00 EDT 1990},
month = {Mon Oct 01 00:00:00 EDT 1990}
}
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Technical Report:
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DOI:  10.2172/6365510
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