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Title: Phenomenological models

Abstract

The biological effects of ionizing radiation exposure are the result of a complex sequence of physical, chemical, biochemical, and physiological interactions. One way to begin a search for an understanding of health effects of radiation is through the development of phenomenological models of the response. Many models have been presented and tested in the slowly evolving process of characterizing cellular response. A range of models covering different endpoints and phenomena has developed in parallel. Many of these models employ similar assumptions about some underlying processes while differing about the nature of others. An attempt is made to organize many of the models into groups with similar features and to compare the consequences of those features with the actual experimental observations. It is assumed that by showing that some assumptions are inconsistent with experimental observations, the job of devising and testing mechanistic models can be simplified. 43 refs., 13 figs.

Authors:
Publication Date:
Research Org.:
Pacific Northwest Lab., Richland, WA (USA)
Sponsoring Org.:
DOE/ER
OSTI Identifier:
6365078
Report Number(s):
PNL-SA-18754; CONF-9009267-3
ON: DE91004737
DOE Contract Number:
AC06-76RL01830
Resource Type:
Conference
Resource Relation:
Conference: Physical and chemical mechanisms in molecular radiation biology conference, Woods Hole, MA (USA), 3-7 Sep 1990
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ACUTE IRRADIATION; RADIATION HAZARDS; ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; MATHEMATICAL MODELS; CELL CYCLE; CHROMOSOMAL ABERRATIONS; DNA; DNA REPAIR; DOSE RATES; LET; RADIATION QUALITY; ACUTE EXPOSURE; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; ENERGY TRANSFER; HAZARDS; HEALTH HAZARDS; IRRADIATION; MUTATIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RECOVERY; REPAIR; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture

Citation Formats

Braby, L.A.. Phenomenological models. United States: N. p., 1990. Web.
Braby, L.A.. Phenomenological models. United States.
Braby, L.A.. Sat . "Phenomenological models". United States. doi:. https://www.osti.gov/servlets/purl/6365078.
@article{osti_6365078,
title = {Phenomenological models},
author = {Braby, L.A.},
abstractNote = {The biological effects of ionizing radiation exposure are the result of a complex sequence of physical, chemical, biochemical, and physiological interactions. One way to begin a search for an understanding of health effects of radiation is through the development of phenomenological models of the response. Many models have been presented and tested in the slowly evolving process of characterizing cellular response. A range of models covering different endpoints and phenomena has developed in parallel. Many of these models employ similar assumptions about some underlying processes while differing about the nature of others. An attempt is made to organize many of the models into groups with similar features and to compare the consequences of those features with the actual experimental observations. It is assumed that by showing that some assumptions are inconsistent with experimental observations, the job of devising and testing mechanistic models can be simplified. 43 refs., 13 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Sep 01 00:00:00 EDT 1990},
month = {Sat Sep 01 00:00:00 EDT 1990}
}

Conference:
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