Effects of hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume
The effects of long-term hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume were studied in eight conscious dogs over a 34-day period. Plasma protein concentration (PPC) was decreased by daily plasmapheresis, and the effects of decreasing and increasing sodium intake were measured. By the 12th day of plasmapheresis PPC had decreased to 2.5 g/dl from a control value of 7.2 g/dl, mean arterial pressure had decreased to 78% of control, glomerular filtration rate (GFR) was 75.2% of control, and urinary sodium excretion was decreased. By day 18 of plasmapheresis, estimated renal plasma flow (ERPF) was decreased to 60% of control due to the decreased arterial pressure and an increase in renal vascular resistance. GFR and ERPF were determined from the total clearance of (/sup 125/I)iothalamate and (/sup 131/I)iodohippurate. Also, plasma renin activity and plasma aldosterone concentration were both increased, and the relationship between mean arterial pressure and urinary sodium excretion was distinctly shifted to the left along the arterial pressure axis. In contradistinction to acute experiments, chronic hypoproteinemia results in decreases in GFR, ERPF, and urinary sodium excretion and has marked effects on both fluid volume and arterial pressure regulation.
- Research Organization:
- Univ. of Mississippi Medical Center, Jackson
- OSTI ID:
- 6351774
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 252:1
- Country of Publication:
- United States
- Language:
- English
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KIDNEYS
DYNAMIC FUNCTION STUDIES
LABELLED COMPOUNDS
RENAL CLEARANCE
PROTEINS
NUTRITIONAL DEFICIENCY
BLOOD CHEMISTRY
BLOOD PRESSURE
DOGS
GLOMERULI
HIPPURAN
IODINE 125
IODINE 131
METABOLIC DISEASES
ULTRAFILTRATION
URINE
VOLUME
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CLEARANCE
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
FILTRATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SEPARATION PROCESSES
VERTEBRATES
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551001* - Physiological Systems- Tracer Techniques