Effects of arsenic, tin, tellurium, and lead on selenium toxicity in chicks
Selenium fed as H/sub 2/SeO/sub 3/ at 25 ppm in a corn-soybean meal diet reduced the growth rate of chicks to approximately 20% of the control values at three weeks of age. Addition of arsenic as AsCl/sub 3/ at 50 ppm, tin as SnCl/sub 2/ at 200 ppm, and tellurium as K/sub 2/TeO/sub 3/ at 200 ppm partially alleviated the growth depression caused by the selenium, demonstrating interaction between selenium and each of these elements. Arsenic increased the growth rate to approximately 74% of control values, tin to approximately 47% of control values, and tellurium to approximately 37% of control values. Lead as PbCl/sub 2/ at 200 ppm and tellurium as TeO/sub 2/ did not significantly affect the growth depression caused by selenium. Arsenic at 10 ppm, tin at 100 ppm, and tellurium at 100 ppm reduced selenium toxicity as measured by weight gain and liver weight. Liver concentrations of selenium in chicks receiving only added selenium ranged from 3.3 to 3.7 ppm. Arsenic fed at 30 to 50 ppm reduced liver selenium concentrations. Tellurium at 400 to 500 ppm and lead at 200 ppm in combination with selenium increased liver selenium concentrations, while tin at 10 to 200 ppm had no effect. These data suggest that the concentration of selenium in the liver of chicks is not always correlated with the toxicity of selenium.
- Research Organization:
- North Carolina State Univ., Raleigh
- OSTI ID:
- 6333867
- Journal Information:
- Fed. Proc.; (United States), Vol. 36:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
SELENIUM
BIOLOGICAL EFFECTS
TOXICITY
ANIMAL GROWTH
ARSENIC
CHICKENS
COMPARATIVE EVALUATIONS
INHIBITION
LEAD
TELLURIUM
TIN
ANIMALS
BIRDS
ELEMENTS
FOWL
GROWTH
METALS
SEMIMETALS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)