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Title: Zinc metabolism in genetically obese (ob/ob) mice

Abstract

Recent reports indicate that the concentrations and total amounts of several essential trace metals in various tissues of genetically obese rodents differ markedly from those in lean controls. In the present studies the absorption, retention and tissue distribution of zinc and constitutive levels of zinc-metallothionein (Zn-MT) in selected tissues were compared in obese (ob/ob) and lean (+/.) C57BL/6J mice. When 5-, 10- and 22-wk-old mice were administered 1.2 mumol /sup 65/Zn by stomach tube the apparent absorption of /sup 65/Zn by obese mice was 1.5, 2.2 and 3.9 times higher, respectively, than that in age-matched lean mice. Retention of orally administered /sup 65/Zn after 96 h was also substantially higher in obese mice than in lean mice. To assess the possible influences of hyperphagia and intestinal hypertrophy on the enhanced apparent absorption of /sup 65/Zn by obese mice food intake by an additional group of obese mice was restricted to that of age-matched lean controls. When actual absorption of zinc was determined according to the method of Heth and Hoekstra, groups of ad libitum--fed obese, pair-fed obese and lean mice absorbed 38, 32 and 18% of administered /sup 65/Zn, respectively. In contrast, the rate of /sup 65/Zn excretion 2-6 dmore » after oral or subcutaneous administration of the metal was similar for obese and lean mice. Unrestricted and pair-fed obese mice had significantly lower percentages of carcass /sup 65/Zn present in skin, muscle plus bone, spleen and testes and higher percentages present in liver, small intestine and adipose tissue than lean mice.« less

Authors:
;
Publication Date:
Research Org.:
Virginia Polytechnic Institute and State Univ., Blacksburg
OSTI Identifier:
6326653
Alternate Identifier(s):
OSTI ID: 6326653
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Nutr.; (United States); Journal Volume: 5
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ZINC; INTESTINAL ABSORPTION; METABOLISM; TISSUE DISTRIBUTION; ADIPOSE TISSUE; METALLOTHIONEIN; MICE; TRACER TECHNIQUES; ZINC 65; ABSORPTION; ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CONNECTIVE TISSUE; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; METALLOPROTEINS; METALS; NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; RODENTS; TISSUES; UPTAKE; VERTEBRATES; ZINC ISOTOPES 560300* -- Chemicals Metabolism & Toxicology; 550501 -- Metabolism-- Tracer Techniques

Citation Formats

Kennedy, M.L., and Failla, M.L. Zinc metabolism in genetically obese (ob/ob) mice. United States: N. p., 1987. Web.
Kennedy, M.L., & Failla, M.L. Zinc metabolism in genetically obese (ob/ob) mice. United States.
Kennedy, M.L., and Failla, M.L. Fri . "Zinc metabolism in genetically obese (ob/ob) mice". United States.
@article{osti_6326653,
title = {Zinc metabolism in genetically obese (ob/ob) mice},
author = {Kennedy, M.L. and Failla, M.L.},
abstractNote = {Recent reports indicate that the concentrations and total amounts of several essential trace metals in various tissues of genetically obese rodents differ markedly from those in lean controls. In the present studies the absorption, retention and tissue distribution of zinc and constitutive levels of zinc-metallothionein (Zn-MT) in selected tissues were compared in obese (ob/ob) and lean (+/.) C57BL/6J mice. When 5-, 10- and 22-wk-old mice were administered 1.2 mumol /sup 65/Zn by stomach tube the apparent absorption of /sup 65/Zn by obese mice was 1.5, 2.2 and 3.9 times higher, respectively, than that in age-matched lean mice. Retention of orally administered /sup 65/Zn after 96 h was also substantially higher in obese mice than in lean mice. To assess the possible influences of hyperphagia and intestinal hypertrophy on the enhanced apparent absorption of /sup 65/Zn by obese mice food intake by an additional group of obese mice was restricted to that of age-matched lean controls. When actual absorption of zinc was determined according to the method of Heth and Hoekstra, groups of ad libitum--fed obese, pair-fed obese and lean mice absorbed 38, 32 and 18% of administered /sup 65/Zn, respectively. In contrast, the rate of /sup 65/Zn excretion 2-6 d after oral or subcutaneous administration of the metal was similar for obese and lean mice. Unrestricted and pair-fed obese mice had significantly lower percentages of carcass /sup 65/Zn present in skin, muscle plus bone, spleen and testes and higher percentages present in liver, small intestine and adipose tissue than lean mice.},
doi = {},
journal = {J. Nutr.; (United States)},
number = ,
volume = 5,
place = {United States},
year = {Fri May 01 00:00:00 EDT 1987},
month = {Fri May 01 00:00:00 EDT 1987}
}