Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain
Journal Article
·
· Life Sci.; (United States)
The histamine-H/sub 1/ receptor blocking properties of a number of structurally different antidepressant drugs have been evaluated using a /sup 3/H-mepyramine binding assay and a guinea-pig ileum preparation. The tricyclic antidepressants all inhibited the histamine-H/sub 1/ receptor. Some newer antidepressant drugs, such as zimeldine and nomifensine were devoid of activity while others, such as iprindole and mianserin were very potent. It is concluded that antagonistic effects on the histamine-H/sub 1/ receptor is not associated with the therapeutic efficacy in depression, but may contribute to the sedative effects of the antidepressant drugs.
- Research Organization:
- Research and Development Lab., Soedertaelje, Sweden
- OSTI ID:
- 6304590
- Journal Information:
- Life Sci.; (United States), Vol. 34:6
- Country of Publication:
- United States
- Language:
- English
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+4 more
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANTIDEPRESSANTS
RADIOASSAY
ANTIHISTAMINICS
BRAIN
CHEMICAL BONDS
GUINEA PIGS
HISTAMINE
LABELLED COMPOUNDS
RECEPTORS
SMALL INTESTINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMALS
AZOLES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INTESTINES
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
ANTIDEPRESSANTS
RADIOASSAY
ANTIHISTAMINICS
BRAIN
CHEMICAL BONDS
GUINEA PIGS
HISTAMINE
LABELLED COMPOUNDS
RECEPTORS
SMALL INTESTINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMALS
AZOLES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INTESTINES
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques