Ki-67 immunostaining in uveal melanoma. The effect of pre-enucleation radiotherapy

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Ophthalmology (Rochester, Minnesota); (USA)

DOI:https://doi.org/10.1016/S0161-6420(90)32420-X· OSTI ID:6290173

Mooy, C M; de Jong, P T; Van der Kwast, T H; Mulder, P G; Jager, M J; Ruiter, D J ^[1]

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1. Erasmus Univ., Rotterdam (Netherlands)

The reactivity of 33 choroidal and ciliary body melanomas with monoclonal antibody Ki-67, which recognizes a proliferation associated nuclear antigen, has been assessed and compared with clinicopathologic parameters. In 23 cases, 8 Gy irradiation was given 2 days before enucleation. Nonirradiated melanomas had a significantly higher proliferation rate as defined by staining with monoclonal antibody Ki-67 as compared with irradiated tumors (P = 0.007). Similarly, a strong relationship was found between pre-enucleation irradiation and low mitotic activity (P = 0.001). There was no significant correlation between the presence of Ki-67-positive nuclei and histologic classification, largest tumor diameter, localization of the tumor, age, sex, scleral invasion, pigmentation, and lymphocytic infiltration. The relevance of Ki-67 immunohistochemistry for the assessment of the life prognosis of patients with uveal melanoma has to be studied prospectively.

• OSTI ID: 6290173
• Journal Information: Ophthalmology (Rochester, Minnesota); (USA), Vol. 97:10; ISSN 0161-6420
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MELANOMAS
RADIOIMMUNOTHERAPY
TUMOR CELLS
CELL PROLIFERATION
UVEA
PATIENTS
ANIMAL CELLS
BODY
BODY AREAS
DISEASES
EYES
FACE
HEAD
IMMUNOLOGY
IMMUNOTHERAPY
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOIMMUNOLOGY
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)