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Title: Detection of myocardial infarct extension by CK-B radioimmunoassay. [/sup 125/I; creatine kinase-B]

Abstract

Myocardial infarct extension after the acute event was defined as a second rise in the myocardial isoenzyme of serum creatine kinase (CK-B) after the initial return of CK-B to normal values. In 43 patients with acute myocardial infarct, CK-B was measured by radioimmunoassay every 12 hrs for 14 days. Nineteen patients had anterior transmural myocardial infarcts (AMI), 14 had inferior transmural myocardial infarcts (IMI), and 10 had subendocardial myocardial infarcts (SEMI). Infarct extension as detected by a second rise in serum CK-B occurred in six patients (32%) with AMI, two (14%) with IMI, and two (20%) with SEMI. Four patients with AMI also had clinically evident infarct extension. In the other six, the infarct extension was undetected clinically. The measurement of serum CK-B values with a quantitative and sensitive assay suggests that myocardial infarct extension occurs more commonly than clinically recognized, but the frequency of extension may be less than that reported in patients in whom precordial mapping and total serum CK values were measured to identify this phenomenon.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of Texas Southwestern Medical School, Dallas
OSTI Identifier:
6289812
Resource Type:
Journal Article
Journal Name:
Circulation; (United States)
Additional Journal Information:
Journal Volume: 59:2
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MYOCARDIAL INFARCTION; DIAGNOSIS; MYOCARDIUM; SCINTISCANNING; PHOSPHOTRANSFERASES; RADIOIMMUNOASSAY; TECHNETIUM 99; BLOOD SERUM; CREATINE; IMMUNE SERUMS; IODINE 125; ISOENZYMES; ISOMERIC NUCLEI; LABELLED COMPOUNDS; PATIENTS; PYROPHOSPHATES; TIN COMPLEXES; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPLEXES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ENZYMES; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RADIOASSAY; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRACER TECHNIQUES; TRANSFERASES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Rothkopf, M., Boerner, J., Stone, M.J., Smitherman, T.C., Buja, L.M., Parkey, R.W., and Willerson, J.T. Detection of myocardial infarct extension by CK-B radioimmunoassay. [/sup 125/I; creatine kinase-B]. United States: N. p., 1979. Web. doi:10.1161/01.CIR.59.2.268.
Rothkopf, M., Boerner, J., Stone, M.J., Smitherman, T.C., Buja, L.M., Parkey, R.W., & Willerson, J.T. Detection of myocardial infarct extension by CK-B radioimmunoassay. [/sup 125/I; creatine kinase-B]. United States. doi:10.1161/01.CIR.59.2.268.
Rothkopf, M., Boerner, J., Stone, M.J., Smitherman, T.C., Buja, L.M., Parkey, R.W., and Willerson, J.T. Thu . "Detection of myocardial infarct extension by CK-B radioimmunoassay. [/sup 125/I; creatine kinase-B]". United States. doi:10.1161/01.CIR.59.2.268.
@article{osti_6289812,
title = {Detection of myocardial infarct extension by CK-B radioimmunoassay. [/sup 125/I; creatine kinase-B]},
author = {Rothkopf, M. and Boerner, J. and Stone, M.J. and Smitherman, T.C. and Buja, L.M. and Parkey, R.W. and Willerson, J.T.},
abstractNote = {Myocardial infarct extension after the acute event was defined as a second rise in the myocardial isoenzyme of serum creatine kinase (CK-B) after the initial return of CK-B to normal values. In 43 patients with acute myocardial infarct, CK-B was measured by radioimmunoassay every 12 hrs for 14 days. Nineteen patients had anterior transmural myocardial infarcts (AMI), 14 had inferior transmural myocardial infarcts (IMI), and 10 had subendocardial myocardial infarcts (SEMI). Infarct extension as detected by a second rise in serum CK-B occurred in six patients (32%) with AMI, two (14%) with IMI, and two (20%) with SEMI. Four patients with AMI also had clinically evident infarct extension. In the other six, the infarct extension was undetected clinically. The measurement of serum CK-B values with a quantitative and sensitive assay suggests that myocardial infarct extension occurs more commonly than clinically recognized, but the frequency of extension may be less than that reported in patients in whom precordial mapping and total serum CK values were measured to identify this phenomenon.},
doi = {10.1161/01.CIR.59.2.268},
journal = {Circulation; (United States)},
number = ,
volume = 59:2,
place = {United States},
year = {1979},
month = {2}
}