Influence of vitamin E on the lung fatty acids of rats exposed to ozone
Rats were fed basal diet that was either free of vitamin E or containing 100 mg/kg of the vitamin, and then exposed to 1.0 ppm O/sub 3/. Mean survival time (50%) was 8.2 days in depleted group and 18.5 days in supplemented group. Protective action was thus demonstrated. O/sub 3/ toxicity symptoms included respiratory difficulty, increased respiratory rate, massive pulmonary edema and hemorrhage, and death. Other rats were exposed to 0.5 ppm for 6 wk. O/sub 3/ caused slight increase in lung weight (% body wt.) of E-supplemented rats and pronounced increase in E-depleted rats, which also showed other signs of O/sub 3/ toxicity. Lung-tissue fatty acid changes predicting edema included increase in arachidonic acid, but other unsaturated acids remained relatively constant. While mortality protection indicates peroxidation as O/sub 3/ toxicity mechanism, fatty acid analyses show quite the opposite. (i.e., surfactant lipids stable).
- OSTI ID:
- 6287278
- Journal Information:
- Arch. Environ. Health; (United States), Vol. 24
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
OZONE
BIOLOGICAL EFFECTS
PATHOLOGY
PHYSIOLOGY
RESPIRATORY TRACT CELLS
VITAMIN E
ARACHIDONIC ACID
RATS
ANIMAL CELLS
ANIMALS
CARBOXYLIC ACIDS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560301 - Chemicals Metabolism & Toxicology- Cells- (-1987)