Stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor

Journal Article · Thu Sep 01 00:00:00 EDT 1988 · Risk Anal.; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1988.tb00502.x· OSTI ID:6277709

Moolgavkar, S H; Dewanji, A; Venzon, D J

The authors present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.

• Research Organization: Fred Hutchinson Cancer Research Center, Seattle, WA (USA)
• OSTI ID: 6277709
• Journal Information: Risk Anal.; (United States), Vol. 8:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
STATISTICAL MODELS
HUMAN POPULATIONS
HEALTH HAZARDS
NEOPLASMS
RISK ASSESSMENT
ANIMAL CELLS
BIOLOGICAL EFFECTS
CARCINOGENS
CYTOLOGY
DOSE LIMITS
DOSE-RESPONSE RELATIONSHIPS
GROWTH
KOLMOGOROV EQUATION
PROBABILITY
STOCHASTIC PROCESSES
TIME DEPENDENCE
TUMOR CELLS
BIOLOGY
DIFFERENTIAL EQUATIONS
DISEASES
EQUATIONS
HAZARDS
MATHEMATICAL MODELS
PATHOGENESIS
POPULATIONS
SAFETY STANDARDS
STANDARDS
560300* - Chemicals Metabolism & Toxicology