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Title: Stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor

Abstract

The authors present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.

Authors:
; ;
Publication Date:
Research Org.:
Fred Hutchinson Cancer Research Center, Seattle, WA (USA)
OSTI Identifier:
6277709
Resource Type:
Journal Article
Journal Name:
Risk Anal.; (United States)
Additional Journal Information:
Journal Volume: 8:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOGENESIS; STATISTICAL MODELS; HUMAN POPULATIONS; HEALTH HAZARDS; NEOPLASMS; RISK ASSESSMENT; ANIMAL CELLS; BIOLOGICAL EFFECTS; CARCINOGENS; CYTOLOGY; DOSE LIMITS; DOSE-RESPONSE RELATIONSHIPS; GROWTH; KOLMOGOROV EQUATION; PROBABILITY; STOCHASTIC PROCESSES; TIME DEPENDENCE; TUMOR CELLS; BIOLOGY; DIFFERENTIAL EQUATIONS; DISEASES; EQUATIONS; HAZARDS; MATHEMATICAL MODELS; PATHOGENESIS; POPULATIONS; SAFETY STANDARDS; STANDARDS; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Moolgavkar, S H, Dewanji, A, and Venzon, D J. Stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor. United States: N. p., 1988. Web. doi:10.1111/j.1539-6924.1988.tb00502.x.
Moolgavkar, S H, Dewanji, A, & Venzon, D J. Stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor. United States. doi:10.1111/j.1539-6924.1988.tb00502.x.
Moolgavkar, S H, Dewanji, A, and Venzon, D J. Thu . "Stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor". United States. doi:10.1111/j.1539-6924.1988.tb00502.x.
@article{osti_6277709,
title = {Stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor},
author = {Moolgavkar, S H and Dewanji, A and Venzon, D J},
abstractNote = {The authors present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.},
doi = {10.1111/j.1539-6924.1988.tb00502.x},
journal = {Risk Anal.; (United States)},
number = ,
volume = 8:3,
place = {United States},
year = {1988},
month = {9}
}