Molecular biology of the renin-angiotensin system

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:6254462

Dzau, V J; Burt, D W; Pratt, R E ^[1]

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1. Harvard Medical School, Boston, MA (USA)

This paper reviews the molecular biology of the renin-angiotensin system. The renin gene structure is analyzed in detail, including an examination of the putative regulatory regions. The combined action of these regulatory sequences would result in the complex, tissue-specific expression and regulation observed in vivo. The expression of the tissue renin-angiotensin systems, which may have important physiological functions, is also described. In addition, the pathway of renin biosynthesis and secretion is reviewed. This includes speculation on the fate of circulating prorenin and the physiological role of multiple renin forms and secretory pathways. The molecular approaches described in this paper have greatly advanced our knowledge of the biology of the renin-angiotensin system. Future studies using these and other approaches should provide further insight into this complex system.

• OSTI ID: 6254462
• Journal Information: American Journal of Physiology; (USA), Vol. 255:4; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
GENE REGULATION
GENES
MOLECULAR BIOLOGY
RENIN
ADRENAL GLANDS
AMINO ACID SEQUENCE
BIOSYNTHESIS
BLOOD VESSELS
BRAIN
HEART
KIDNEYS
MAN
MICE
RATS
TESTES
ANIMALS
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DRUGS
ENDOCRINE GLANDS
ENZYMES
GLANDS
GLOBULINS
GONADS
HYDROLASES
MALE GENITALS
MAMMALS
MOLECULAR STRUCTURE
NERVOUS SYSTEM
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PRIMATES
PROTEINS
RODENTS
SYNTHESIS
VASOCONSTRICTORS
VERTEBRATES
550200* - Biochemistry