skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia

Abstract

In rats anesthetized with ketamine and pentobarbital (KET/PB), vasoactive intestinal peptide (VIP) increases vascular conductance (VC) in the salivary gland, pancreas, and thyroid gland, whereas no changes in VC are observed in a number of other organs. Because anesthesia may alter the responsiveness of physiological systems, we compared the effects of VIP on organ VC in conscious or anesthetized rats. Chronically catheterized rats were studied in the conscious state or 30 min after induction of anesthesia with KET/PB, isoflurane, or Inactin. Blood flows were measured by the reference sample version of the radioactive microsphere (MS) technique using two MS injections ({sup 141}Ce-MS/{sup 85}Sr-MS). Mean arterial blood pressure was monitored and used in the calculation of VC. Organ VCs were similar under basal conditions in conscious and anesthetized rats. VIP infusion caused systemic hypotension and increased VCs in the salivary gland, pancreas, and thyroid gland, and these responses were largely unaffected by anesthesia. These results indicate that the anesthetics used do not alter basal VC or the responsiveness of the vasculature to exogenous VIP.

Authors:
; ;  [1]
  1. (West Virginia Univ. Medical Center, Morgantown (USA))
Publication Date:
OSTI Identifier:
6252501
Resource Type:
Journal Article
Journal Name:
American Journal of Physiology; (USA)
Additional Journal Information:
Journal Volume: 255:6; Journal ID: ISSN 0002-9513
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; LTH; RADIOIMMUNOASSAY; PEPTIDES; BIOLOGICAL EFFECTS; TSH; ANESTHESIA; BLOOD PRESSURE; BLOOD VESSELS; RATS; ANIMALS; BIOASSAY; BODY; CARDIOVASCULAR SYSTEM; DIAGNOSTIC TECHNIQUES; GONADOTROPINS; HORMONES; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RADIOIMMUNOLOGY; RODENTS; TRACER TECHNIQUES; VERTEBRATES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Bouder, T.G., Huffman, L.J., and Hedge, G.A. Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia. United States: N. p., 1988. Web.
Bouder, T.G., Huffman, L.J., & Hedge, G.A. Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia. United States.
Bouder, T.G., Huffman, L.J., and Hedge, G.A. Thu . "Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia". United States.
@article{osti_6252501,
title = {Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia},
author = {Bouder, T.G. and Huffman, L.J. and Hedge, G.A.},
abstractNote = {In rats anesthetized with ketamine and pentobarbital (KET/PB), vasoactive intestinal peptide (VIP) increases vascular conductance (VC) in the salivary gland, pancreas, and thyroid gland, whereas no changes in VC are observed in a number of other organs. Because anesthesia may alter the responsiveness of physiological systems, we compared the effects of VIP on organ VC in conscious or anesthetized rats. Chronically catheterized rats were studied in the conscious state or 30 min after induction of anesthesia with KET/PB, isoflurane, or Inactin. Blood flows were measured by the reference sample version of the radioactive microsphere (MS) technique using two MS injections ({sup 141}Ce-MS/{sup 85}Sr-MS). Mean arterial blood pressure was monitored and used in the calculation of VC. Organ VCs were similar under basal conditions in conscious and anesthetized rats. VIP infusion caused systemic hypotension and increased VCs in the salivary gland, pancreas, and thyroid gland, and these responses were largely unaffected by anesthesia. These results indicate that the anesthetics used do not alter basal VC or the responsiveness of the vasculature to exogenous VIP.},
doi = {},
journal = {American Journal of Physiology; (USA)},
issn = {0002-9513},
number = ,
volume = 255:6,
place = {United States},
year = {1988},
month = {12}
}