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Title: Effect of dietary vitamin E level on the biochemical response of rat lung to ozone inhalation

Abstract

We examined the effects of dietary vitamin E level on rat lung response to ozone (O3) inhalation. In one study, we fed 1-month-old Sprague-Dawley (SD) rats a test diet containing 0 or 50 IU vitamin E/kg for 2 months, and then exposed one-half of the animals from each dietary group to 0.8 ppm (1,568 micrograms/m3) O3 intermittently (8 hours daily) and the other half to room air for 7 days. After O3 exposure, we found significant increases in marker enzyme activities in rat lungs from both dietary groups relative to corresponding air-exposed controls, but the magnitude of increases was greater for the 0 IU than the 50 IU group. In another study, we fed 1-month-old SD rats a test diet containing 10, 50, or 500 IU vitamin E/kg for 2 months and then exposed one-half of the animals from each dietary group to 0.8 ppm (1,568 micrograms/m3) O3 continuously and the other half to room air for 4 days. The O3 exposure increased the metabolic activities in rat lungs from all three dietary groups relative to corresponding air-exposed controls, but the magnitude of increases was greater for the 10 IU than the 50 IU or 500 IU group, and themore » difference between the 50 IU and 500 IU groups was small. Because a greater increase in lung metabolism after O3 exposure is thought to be associated with a greater tissue injury, the results suggest that an absence of dietary vitamin E exacerbates lung injury from O3 inhalation, while its presence protects from injury. However, the magnitude of this protective effect does not increase proportionately with increased dietary vitamin E supplementation beyond a certain level.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of California, Los Angeles (USA)
OSTI Identifier:
6251727
Resource Type:
Journal Article
Journal Name:
Drug Nutr. Interact; (United States)
Additional Journal Information:
Journal Volume: 5:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LUNGS; PATHOLOGICAL CHANGES; OZONE; TOXICITY; VITAMIN E; BIOLOGICAL EFFECTS; DIET; ENZYME ACTIVITY; GLUCOSE; GLUTATHIONE; INHALATION; METABOLISM; MICROSOMES; MITOCHONDRIA; OXIDOREDUCTASES; OXYGEN; RATS; ALDEHYDES; ANIMALS; BODY; CARBOHYDRATES; CELL CONSTITUENTS; DRUGS; ELEMENTS; ENZYMES; HEXOSES; INTAKE; MAMMALS; MONOSACCHARIDES; NONMETALS; ORGANIC COMPOUNDS; ORGANOIDS; ORGANS; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RESPIRATORY SYSTEM; RODENTS; SACCHARIDES; VERTEBRATES; VITAMINS; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Elsayed, N M, Kass, R, Mustafa, M G, Hacker, A D, Ospital, J J, Chow, C K, and Cross, C E. Effect of dietary vitamin E level on the biochemical response of rat lung to ozone inhalation. United States: N. p., 1988. Web.
Elsayed, N M, Kass, R, Mustafa, M G, Hacker, A D, Ospital, J J, Chow, C K, & Cross, C E. Effect of dietary vitamin E level on the biochemical response of rat lung to ozone inhalation. United States.
Elsayed, N M, Kass, R, Mustafa, M G, Hacker, A D, Ospital, J J, Chow, C K, and Cross, C E. Fri . "Effect of dietary vitamin E level on the biochemical response of rat lung to ozone inhalation". United States.
@article{osti_6251727,
title = {Effect of dietary vitamin E level on the biochemical response of rat lung to ozone inhalation},
author = {Elsayed, N M and Kass, R and Mustafa, M G and Hacker, A D and Ospital, J J and Chow, C K and Cross, C E},
abstractNote = {We examined the effects of dietary vitamin E level on rat lung response to ozone (O3) inhalation. In one study, we fed 1-month-old Sprague-Dawley (SD) rats a test diet containing 0 or 50 IU vitamin E/kg for 2 months, and then exposed one-half of the animals from each dietary group to 0.8 ppm (1,568 micrograms/m3) O3 intermittently (8 hours daily) and the other half to room air for 7 days. After O3 exposure, we found significant increases in marker enzyme activities in rat lungs from both dietary groups relative to corresponding air-exposed controls, but the magnitude of increases was greater for the 0 IU than the 50 IU group. In another study, we fed 1-month-old SD rats a test diet containing 10, 50, or 500 IU vitamin E/kg for 2 months and then exposed one-half of the animals from each dietary group to 0.8 ppm (1,568 micrograms/m3) O3 continuously and the other half to room air for 4 days. The O3 exposure increased the metabolic activities in rat lungs from all three dietary groups relative to corresponding air-exposed controls, but the magnitude of increases was greater for the 10 IU than the 50 IU or 500 IU group, and the difference between the 50 IU and 500 IU groups was small. Because a greater increase in lung metabolism after O3 exposure is thought to be associated with a greater tissue injury, the results suggest that an absence of dietary vitamin E exacerbates lung injury from O3 inhalation, while its presence protects from injury. However, the magnitude of this protective effect does not increase proportionately with increased dietary vitamin E supplementation beyond a certain level.},
doi = {},
url = {https://www.osti.gov/biblio/6251727}, journal = {Drug Nutr. Interact; (United States)},
number = ,
volume = 5:4,
place = {United States},
year = {1988},
month = {1}
}