Subcellular localization of HPA-23 in different rat organs: Electron microprobe study

Journal Article · Sat Dec 01 00:00:00 EST 1990 · Experimental and Molecular Pathology; (USA)

DOI:https://doi.org/10.1016/0014-4800(90)90048-I· OSTI ID:6247871

Berry, J P; Galle, P ^[1]

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1. Centre de Microanalyse Appliquee a la Biologie du CNRS, Creteil (France)

The anti-viral drug HPA-23 (ammonium 21-tungsto-9-antimonate) has been proposed for use in the combat against AIDS. The two elements tungsten (W) and antimony (Sb) in the molecule enable the intracellular localization and possible breakdown of the product to be studied using electron probe microanalysis methods. Such studies have been carried out after intravenous injection of different doses of HPA-23 in the rat followed by removal of the liver, kidney, thymus, spleen, bone marrow, and lung. HPA-23 was concentrated in the lysosomes and localized in the macrophages of different tissues (thymus, spleen, and bone marrow). The W/Sb ratio was identical in these macrophages. This localization is perhaps relevant to the mechanism of action of HPA-23.

• OSTI ID: 6247871
• Journal Information: Experimental and Molecular Pathology; (USA), Vol. 53:3; ISSN 0014-4800
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
CHEMOTHERAPY
ANTIBIOTICS
SUBCELLULAR DISTRIBUTION
AIDS VIRUS
ANTIMONY
DOSE-RESPONSE RELATIONSHIPS
ELECTRON MICROPROBE ANALYSIS
LYSOSOMES
MACROPHAGES
RATS
TUNGSTEN
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
CELL CONSTITUENTS
CHEMICAL ANALYSIS
CONNECTIVE TISSUE CELLS
DISEASES
DISTRIBUTION
DRUGS
ELEMENTS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
MAMMALS
METALS
MICROANALYSIS
MICROORGANISMS
ORGANOIDS
PARASITES
PHAGOCYTES
RODENTS
SOMATIC CELLS
THERAPY
TRANSITION ELEMENTS
VERTEBRATES
VIRAL DISEASES
VIRUSES
550602* - Medicine- External Radiation in Diagnostics- (1980-)