skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Influence of usual zinc intake and zinc in a meal on /sup 65/Zn retention and turnover in the rat

Abstract

The influences of zinc in a meal and usual zinc intake on zinc retention and turnover were investigated in 7-wk-old male rats fed diets containing 12-151 mg Zn/kg for 3 wk before and after consuming a /sup 65/Zn-labeled meal containing ZnCl/sub 2/. Retention corrected to zero time and turnover rate were determined by whole-body counting. Percent zinc retention was inversely proportional to the natural logarithm of the meal zinc, between 0.09 and 26 mumol. In comparison to lower doses, higher doses resulted in lower percent retention but greater amounts of zinc retained. Although the latter relationship was slightly curvilinear, there was no indication of a limited capacity for zinc retention with high doses. However, doses above 4 mumol resulted in higher turnover rates in rats accustomed to lower zinc intakes. Percent retention and the reciprocal of the turnover rate were proportional to the reciprocal of the dietary zinc concentration. The greatest differences in retention and turnover occurred between 12 and 26 mg Zn/kg diet. The zinc dose in a meal and the usual dietary zinc separately influenced percent zinc retention. These factors also interacted, such that greater dose effects were observed at lower zinc intakes and greater dietary zinc effectsmore » were observed at lower doses.« less

Authors:
; ;
Publication Date:
Research Org.:
Dept. of Agriculture, Grand Forks, ND
OSTI Identifier:
6243087
Resource Type:
Journal Article
Journal Name:
J. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 117:8
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ZINC; METABOLISM; RETENTION; BIOLOGICAL EFFECTS; DIET; RATS; REGRESSION ANALYSIS; TRACER TECHNIQUES; WHOLE-BODY COUNTING; ANIMALS; COUNTING TECHNIQUES; ELEMENTS; ISOTOPE APPLICATIONS; MAMMALS; MATHEMATICS; METALS; RODENTS; STATISTICS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 550501 - Metabolism- Tracer Techniques

Citation Formats

Hunt, J R, Johnson, P E, and Swan, P B. Influence of usual zinc intake and zinc in a meal on /sup 65/Zn retention and turnover in the rat. United States: N. p., 1987. Web.
Hunt, J R, Johnson, P E, & Swan, P B. Influence of usual zinc intake and zinc in a meal on /sup 65/Zn retention and turnover in the rat. United States.
Hunt, J R, Johnson, P E, and Swan, P B. Sat . "Influence of usual zinc intake and zinc in a meal on /sup 65/Zn retention and turnover in the rat". United States.
@article{osti_6243087,
title = {Influence of usual zinc intake and zinc in a meal on /sup 65/Zn retention and turnover in the rat},
author = {Hunt, J R and Johnson, P E and Swan, P B},
abstractNote = {The influences of zinc in a meal and usual zinc intake on zinc retention and turnover were investigated in 7-wk-old male rats fed diets containing 12-151 mg Zn/kg for 3 wk before and after consuming a /sup 65/Zn-labeled meal containing ZnCl/sub 2/. Retention corrected to zero time and turnover rate were determined by whole-body counting. Percent zinc retention was inversely proportional to the natural logarithm of the meal zinc, between 0.09 and 26 mumol. In comparison to lower doses, higher doses resulted in lower percent retention but greater amounts of zinc retained. Although the latter relationship was slightly curvilinear, there was no indication of a limited capacity for zinc retention with high doses. However, doses above 4 mumol resulted in higher turnover rates in rats accustomed to lower zinc intakes. Percent retention and the reciprocal of the turnover rate were proportional to the reciprocal of the dietary zinc concentration. The greatest differences in retention and turnover occurred between 12 and 26 mg Zn/kg diet. The zinc dose in a meal and the usual dietary zinc separately influenced percent zinc retention. These factors also interacted, such that greater dose effects were observed at lower zinc intakes and greater dietary zinc effects were observed at lower doses.},
doi = {},
journal = {J. Nutr.; (United States)},
number = ,
volume = 117:8,
place = {United States},
year = {1987},
month = {8}
}