Metabolic changes in deafferented central neurons of an insect, Acheta domesticus. I. Effects upon amino acid uptake and incorporation
Chronic cercal deafferentation of the terminal ganglion in developing crickets (Acheta domesticus), which is known to suppress normal development of giant interneuron dendritic arborizations is shown here to reduce (/sup 3/H)leucine uptake and incorporation into ganglion proteins. Short term deafferentation of adult crickets, in contrast, does not depress amino acid uptake and incorporation significantly. Following unilateral long term deafferentation of the terminal ganglion, a comparison was made of the (/sup 3/H)leucine incorporation into primary dendritic processes and somata of deafferented and normally innervated medial giant interneurons (MGIs) within the same ganglion by means of quantitative autoradiography. Grain densities within dendrites of deafferented MGIs were significantly lower than in paired control MGIs' grain densities within somata of deafferented MGIs also were reduced, although the effects of deafferentation were less pronounced in somata than in target dendrites. These results imply a specific influence of afferent innervation on protein metabolism during growth and development of target postsynaptic elements.
- Research Organization:
- Department of Zoology, University of Washington, Seattle
- OSTI ID:
- 6240594
- Journal Information:
- J. Neurosci.; (United States), Vol. 2:11
- Country of Publication:
- United States
- Language:
- English
Similar Records
Chronic toxicity of nanodiamonds can disturb development and reproduction of Acheta domesticus L
Differential life-stage susceptibility of Acheta domesticus to acridine
Related Subjects
LEUCINE
METABOLISM
NERVE CELLS
PHYSIOLOGY
TRITIUM COMPOUNDS
ISOTOPE APPLICATIONS
INSECTS
ONTOGENESIS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ARTHROPODS
CARBOXYLIC ACIDS
INVERTEBRATES
LABELLED COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
SOMATIC CELLS
550301* - Cytology- Tracer Techniques
550201 - Biochemistry- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques