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Title: Effects of iron, tin, and copper on zinc absorption in humans

Abstract

Zinc absorption as measured by body retention of (65Zn)zinc chloride or a turkey test meal extrinsically labeled with 65Zn was determined in human subjects by whole body counting after 7 days. Average 65Zn absorption from zinc chloride in persons with a high iron-absorbing capacity was similar to persons with a low capacity to absorb iron. Inorganic iron, 920 mumol (51 mg), or HB iron, 480 mumol (26 mg), inhibited 65Zn absorption from 92 mumol (6 mg) of zinc chloride. When 610 mumol of iron (34 mg) was added to a turkey test meal containing 61 mumol of zinc (4 mg), 65Zn absorption was not inhibited. Tin, 306 mumol (36 mg), given with zinc chloride or turkey test meals (61 mumol, 4 mg, of Zn) significantly reduced 65Zn absorption. Copper, 79 mumol (5 mg), had no significant effect on the 65Zn absorption from 7.9 mumol (0.5 mg) of zinc chloride. In summary, the capacity to absorb iron did not influence 65Zn absorption, but both inorganic iron and heme-iron inhibited 65Zn absorption from zinc chloride. Inorganic iron had no effect, however, on 65Zn absorption from the turkey test meal. Tin in a large dose also inhibited 65Zn absorption from both zinc chloridemore » and the turkey test meal.« less

Authors:
; ;
Publication Date:
Research Org.:
Univ. Hospital, London, Ontario, Canada
OSTI Identifier:
6237897
Resource Type:
Journal Article
Journal Name:
Am. J. Clin. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 40:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; COPPER; BIOLOGICAL EFFECTS; IRON; TIN; ZINC; INTESTINAL ABSORPTION; MAN; TRACER TECHNIQUES; WHOLE-BODY COUNTING; ZINC 65; ABSORPTION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; METALS; NUCLEI; PRIMATES; RADIOISOTOPES; TRANSITION ELEMENTS; UPTAKE; VERTEBRATES; ZINC ISOTOPES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Valberg, L S, Flanagan, P R, and Chamberlain, M J. Effects of iron, tin, and copper on zinc absorption in humans. United States: N. p., 1984. Web.
Valberg, L S, Flanagan, P R, & Chamberlain, M J. Effects of iron, tin, and copper on zinc absorption in humans. United States.
Valberg, L S, Flanagan, P R, and Chamberlain, M J. Sat . "Effects of iron, tin, and copper on zinc absorption in humans". United States.
@article{osti_6237897,
title = {Effects of iron, tin, and copper on zinc absorption in humans},
author = {Valberg, L S and Flanagan, P R and Chamberlain, M J},
abstractNote = {Zinc absorption as measured by body retention of (65Zn)zinc chloride or a turkey test meal extrinsically labeled with 65Zn was determined in human subjects by whole body counting after 7 days. Average 65Zn absorption from zinc chloride in persons with a high iron-absorbing capacity was similar to persons with a low capacity to absorb iron. Inorganic iron, 920 mumol (51 mg), or HB iron, 480 mumol (26 mg), inhibited 65Zn absorption from 92 mumol (6 mg) of zinc chloride. When 610 mumol of iron (34 mg) was added to a turkey test meal containing 61 mumol of zinc (4 mg), 65Zn absorption was not inhibited. Tin, 306 mumol (36 mg), given with zinc chloride or turkey test meals (61 mumol, 4 mg, of Zn) significantly reduced 65Zn absorption. Copper, 79 mumol (5 mg), had no significant effect on the 65Zn absorption from 7.9 mumol (0.5 mg) of zinc chloride. In summary, the capacity to absorb iron did not influence 65Zn absorption, but both inorganic iron and heme-iron inhibited 65Zn absorption from zinc chloride. Inorganic iron had no effect, however, on 65Zn absorption from the turkey test meal. Tin in a large dose also inhibited 65Zn absorption from both zinc chloride and the turkey test meal.},
doi = {},
journal = {Am. J. Clin. Nutr.; (United States)},
number = ,
volume = 40:3,
place = {United States},
year = {1984},
month = {9}
}